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344273 Forskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride - CAS 115116-37-5 - Calbiochem

344273
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Overview

Key Spec Table

CAS #Empirical Formula
115116-37-5C₂₉H₄₈N₂O₇ · 2HCl

Products

Catalogue NumberPackaging Qty/Pack
344273-10MG Plastic ampoule 10 mg
344273-5MG Plastic ampoule 5 mg
Description
OverviewChemically-modified forskolin with greater stability and water solubility than the parent compound. Activates adenylate cyclase (EC50 = 13 µM). Inhibits 5HT-stimulated inositol phosphate accumulation in smooth muscle cells.
Catalogue Number344273
Brand Family Calbiochem®
SynonymsL-858051, 8,13-Epoxy-7β-(N-methylpiperazino-γ-butyryloxy)-1α,6β,9α-trihydroxy-labd-14-en-11-one, 2HCl
References
ReferencesYang, C.M., et al. 1999. Cell Signal. 11, 697.
Hartzell, H.C., and Budnitz, D. 1992. Mol. Pharmacol. 41, 880.
Chidiac, P., et al. 1991. J. Mol. Cell. Cardiol. 23, 1255.
Laurenza, A., et al. 1987. Mol. Pharmacol. 32, 133.
Product Information
CAS number115116-37-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₉H₄₈N₂O₇ · 2HCl
Chemical formulaC₂₉H₄₈N₂O₇ · 2HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationForskolin, 7-Deacetyl-7-[O-(N-methylpiperazino)-γ-butyryl]-, Dihydrochloride, CAS 115116-37-5, is a chemically-modified forskolin for greater stability and water solubility.
Biological Information
Primary TargetAdenylate cyclase
Primary Target IC<sub>50</sub>EC50 = 13 µM in activating adenylate cyclase
Purity≥92% by HPLC
Physicochemical Information
Cell permeableN
Safety Information
R PhraseR: 21

Harmful in contact with skin.
S PhraseS: 36

Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +15°C to +30°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.
Global Trade Item Number
Catalogue Number GTIN
344273-10MG 04055977215380
344273-5MG 04055977214642