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14-673M EphA8 Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant, human EphA8 residues 615-911, for use in Kinase Assays.

14-673M
250 µg  Also available in 10 μg size (cat#14-673) and in bulk (cat#14-673-K).
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-673M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionEphA8 Protein, active, 250 µg
OverviewN-terminal 6His-tagged, recombinant, human EphA8 residues 615-911
References
Product Information
Quality LevelMQ300
Applications
ApplicationActive, N-terminal 6His-tagged, recombinant, human EphA8 residues 615-911, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed by baculovirus in Sf21 cells
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.
Gene Symbol
  • EPHA8
  • HEK3
  • KIAA1459
  • EphA8
  • EEK
  • Hek3
Protein TargetEphA8
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyTK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P29322 # Receptor for members of the ephrin-A family.
SIZE: 1005 amino acids; 111003 Da
SUBUNIT: Interacts with FYN (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
PTM: Phosphorylation on Tyr-616 is critical for association with FYN (By similarity). & Phosphorylation on Tyr-839 modulates tyrosine kinase activity (By similarity).
SIMILARITY: SwissProt: P29322 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. & Contains 2 fibronectin type-III domains. & Contains 1 protein kinase domain. & Contains 1 SAM (sterile alpha motif) domain.
Molecular Weight37.1 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by phosphorylation of PDKtide (Catalog # 12-401)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C from date of shipment
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-673) and in bulk (cat#14-673-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-673M 04053252924927

Documentation

Related Products & Applications

Alternative Packsize

Catalogue Number Description
14-673 EphA8 Protein, active, 10 µg

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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Categories

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases