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324410 Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem

Dynamin Inhibitor I, Dynasore, CAS 304448-55-3, is a cell-permeable inhibitor of the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1. Has no significant effect on MxA and Cdc42.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin

324410
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
304448-55-3C₁₈H₁₄N₂O₄

Products

Catalogue NumberPackaging Qty/Pack
324410-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.
Catalogue Number324410
Brand Family Calbiochem®
Synonyms3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin
References
ReferencesYoung, A., et al. 2009. Biochem. J. , In press.
Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol. 16, 607.
Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 17955.
Macia. E., et al. 2006. Dev. Cell 10, 839.
Product Information
CAS number304448-55-3
FormPale yellow solid
Hill FormulaC₁₈H₁₄N₂O₄
Chemical formulaC₁₈H₁₄N₂O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationDynamin Inhibitor I, Dynasore, CAS 304448-55-3, is a cell-permeable inhibitor of the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1. Has no significant effect on MxA and Cdc42.
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 50

Very toxic to aquatic organisms.
S PhraseS: 22-24/25

Do not breathe dust.
Avoid contact with skin and eyes.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Environmental Hazard
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324410-10MG 04055977197167

Documentation

Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Dynamin Inhibitor I, Dynasore - CAS 304448-55-3 - Calbiochem Certificates of Analysis

TitleLot Number
324410

References

Reference overview
Young, A., et al. 2009. Biochem. J. , In press.
Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol. 16, 607.
Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 17955.
Macia. E., et al. 2006. Dev. Cell 10, 839.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-May-2009 RFH
Synonyms3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin
DescriptionA cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number304448-55-3
Chemical formulaC₁₈H₁₄N₂O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (16 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Environmental Hazard
ReferencesYoung, A., et al. 2009. Biochem. J. , In press.
Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol. 16, 607.
Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 17955.
Macia. E., et al. 2006. Dev. Cell 10, 839.