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317700 Dkk-1 Inhibitor, WAY-262611, HCl - Calbiochem

317700
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Overview

Key Spec Table

Empirical Formula
C₂₀H₂₂N₄ • HCl

Products

Catalogue NumberPackaging Qty/Pack
317700-10MG Glass bottle 10 mg
Description
OverviewA 2-aminopyrimidine compound that counteracts the antagonizing effect of Dkk-1 (Dickkopf-1) against Wnt-3a/LRP5 interaction and prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation and internalization. Shown to successfully rescue cellular response to Wnt-3a stimulation in the presence of Dkk-1 (EC50 = 0.63 µM in a cell-based TCF-luciferase assay) in vitro and double the tibia trabecular bone formation in OVX rats in a period of 28 days via an oral dose of 10 mg/kg/day in vivo.
Catalogue Number317700
Brand Family Calbiochem®
Synonyms(1-(4-(Naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine, Wnt Pathway Activator VI
References
ReferencesPelletier, J.C., et al. 2009. J. Med. Chem. 52, 6962.
Product Information
FormYellow powder
FormulationSupplied as a hydrochloride salt.
Hill FormulaC₂₀H₂₂N₄ • HCl
Chemical formulaC₂₀H₂₂N₄ • HCl
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationDkk-1 Inhibitor, WAY-262611, HCl, CAS 1123231-07-1, counteracts the antagonizing effect of Dkk-1 against Wnt-3a/LRP5 interaction. Prevents Dkk-1-mediated Kr2/LRP5/Dkk-1 complex formation.
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
317700-10MG 04055977216288