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217694 Cdc25 Inhibitor IV, NSC 95397 - CAS 93718-83-3 - Calbiochem

The Cdc25 Inhibitor IV, NSC 95397, also referenced under CAS 93718-83-3, controls the biological activity of Cdc25. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphor

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX

217694
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Overview

Key Spec Table

CAS #Empirical Formula
93718-83-3C₁₄H₁₄O₄S₂

Products

Catalogue NumberPackaging Qty/Pack
217694-10MG Glass bottle 10 mg
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Description
OverviewA cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki = 32 nM, 96 nM, and 40 nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50 = 1.8 µM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments.
Catalogue Number217694
Brand Family Calbiochem®
Synonyms(2,3-bis-[2-hydroxyethylsulfanyl]-[1,4]naphthoquinone), PTP Inhibitor XXIX
References
ReferencesDulyaninova, N.G., et al. 2011. Biochemistry 50, 7218.
Lazo, J.S., et al. 2002. Mol. Pharmacol. 61, 720.
Product Information
CAS number93718-83-3
FormOrange solid
Hill FormulaC₁₄H₁₄O₄S₂
Chemical formulaC₁₄H₁₄O₄S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
217694-10MG 04055977202304