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215901 Carbonic Anhydrase IX/XII Inhibitor II, U-104 - Calbiochem

The Carbonic Anhydrase IX/XII Inhibitr II, U-104 controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CAIX Inhibitor II

215901
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₃H₁₂FN₃O₃S

Products

Catalogue NumberPackaging Qty/Pack
215901-5MG Glass bottle 5 mg
Description
OverviewA cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 5080 nM and 9640 nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38 mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.
Catalogue Number215901
Brand Family Calbiochem®
SynonymsCAIX Inhibitor II
References
ReferencesLock, F.E., et al. 2012. Oncogene in press.
Pacchiano, F., et al. 2011. J Med Chem. 54, 1896.
Product Information
FormWhite solid
Hill FormulaC₁₃H₁₂FN₃O₃S
Chemical formulaC₁₃H₁₂FN₃O₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
215901-5MG 04055977219227

Documentation

Carbonic Anhydrase IX/XII Inhibitor II, U-104 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Carbonic Anhydrase IX/XII Inhibitor II, U-104 - Calbiochem Certificates of Analysis

TitleLot Number
215901

References

Reference overview
Lock, F.E., et al. 2012. Oncogene in press.
Pacchiano, F., et al. 2011. J Med Chem. 54, 1896.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-December-2012 JSW
SynonymsCAIX Inhibitor II
DescriptionA cell permeable ureido-sulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 45 nM and 4.5 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 5080 nM and 9640 nM for hCA I and hCA II, respectively). It elicits anti-tumor growth effects dose-dependently from 19 to 38 mg/kg in a mouse tumor growth model implanted with MDA-MB-231 LM2-4Luc+ cells, and demonstrates metastasis inhibition in a mouse metastasis model injected with 4T1 cells.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₃H₁₂FN₃O₃S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesLock, F.E., et al. 2012. Oncogene in press.
Pacchiano, F., et al. 2011. J Med Chem. 54, 1896.