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215900 Carbonic Anhydrase IX/XII Inhibitor - CAS 175014-68-3 - Calbiochem

The Carbonic Anhydrase IX/XII Inhibitor controls the biological activity of Carbonic Anhydrase IX/XII. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CAIX Inhibitor

215900
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
175014-68-3C₁₃H₁₂N₄O₅S

Products

Catalogue NumberPackaging Qty/Pack
215900-5MG Glass bottle 5 mg
Description
OverviewA cell permeable benzenesulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 0.9 nM and 5.7 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 23.4 nM and 15 nM for hCA I and hCA II, respectively), as compared with another CA inhibitor AAZ (Ki = 250 nM, 12 nM, 25 nM, and 5.7 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively). It is shown to effectively inhibit the formation of metastases by 4T1 breast cancer cells in a mouse model dose-dependently at pharmacologic concentrations of 15-45 mg/kg.
Catalogue Number215900
Brand Family Calbiochem®
SynonymsCAIX Inhibitor
References
ReferencesPacchiano, F., et al. 2011. J Med Chem. 54, 1896.
Product Information
CAS number175014-68-3
FormWhite solid
Hill FormulaC₁₃H₁₂N₄O₅S
Chemical formulaC₁₃H₁₂N₄O₅S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
215900-5MG 04055977219210

Documentation

Carbonic Anhydrase IX/XII Inhibitor - CAS 175014-68-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Carbonic Anhydrase IX/XII Inhibitor - CAS 175014-68-3 - Calbiochem Certificates of Analysis

TitleLot Number
215900

References

Reference overview
Pacchiano, F., et al. 2011. J Med Chem. 54, 1896.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-April-2012 JSW
SynonymsCAIX Inhibitor
DescriptionA cell permeable benzenesulfonamide Carbonic Anhydrase (CA) inhibitor that is selective for human hCA IX and hCA XII (Ki = 0.9 nM and 5.7 nM, respectively) against two other physiologically relevant hCA isoforms (Ki = 23.4 nM and 15 nM for hCA I and hCA II, respectively), as compared with another CA inhibitor AAZ (Ki = 250 nM, 12 nM, 25 nM, and 5.7 nM for hCA I, hCA II, hCA IX, and hCA XII, respectively). It is shown to effectively inhibit the formation of metastases by 4T1 breast cancer cells in a mouse model dose-dependently at pharmacologic concentrations of 15-45 mg/kg.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number175014-68-3
Chemical formulaC₁₃H₁₂N₄O₅S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesPacchiano, F., et al. 2011. J Med Chem. 54, 1896.