Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

189497 Autophagy Inducer, STF-62247 - CAS 315702-99-9 - Calbiochem

189497
Purchase on Sigma-Aldrich

Overview

Key Spec Table

CAS #Empirical Formula
315702-99-9C₁₅H₁₃N₃S

Products

Catalogue NumberPackaging Qty/Pack
189497-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable autophagy inducer that selectively induces non-apoptotic cell death in VHL- (von Hippel-Lindau) deficient, but not VHL-expressing, renal carcinoma cells both in vitro (IC50 = 0.625 and 16 µM in RCC4 and RCC4/VHL killing, respectively) and in mice in vivo (>90% 786-O tumor growth suppression; 8 mg/kg via daily i.p.). Although STF-62247 induces autophagy regardless of cellular VHL-expression level, STF-62247 treatment is shown to result in more enhanced/acidified autolysomes formation in VHL-deficient cells, implicating an important role of VHL in maintaining normal vesicular trafficking between ER, TNG, and lysosomes.
Catalogue Number189497
Brand Family Calbiochem®
SynonymsN-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine
References
ReferencesTurcotte, S., et al. 2008. Cancer Cell 14, 90.
Product Information
CAS number315702-99-9
FormBeige solid
Hill FormulaC₁₅H₁₃N₃S
Chemical formulaC₁₅H₁₃N₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Safety Information
R PhraseR: 22-41

Harmful if swallowed.
Risk of serious damage to eyes.
S PhraseS: 26-39

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear eye/face protection.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
189497-10MG 04055977221855