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AB9848 Anti-phospho-Synapsin I (Ser62,Ser67) Antibody

Anti-phospho-Synapsin I Antibody (Ser62, Ser67) detects level of phospho-Synapsin I (Ser62) & has been published & validated for use in WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Synapse & Synaptic Biology Gene Symbol: SYN1, SYN1a, Synapsin-1, SYNI, SYN1b UniProt Number: P17600
AB9848
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
RWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB9848
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-phospho-Synapsin I (Ser62,Ser67) Antibody
References
Product Information
FormatAffinity Purified
PresentationLiquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug/mL BSA and 50% glycerol.
Quality LevelMQ100
Applications
ApplicationAnti-phospho-Synapsin I Antibody (Ser62, Ser67) detects level of phospho-Synapsin I (Ser62) & has been published & validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenSynthetic peptide of amino acids surrounding the phosphoSerine 62,67 site of rat Synapsin I.
HostRabbit
SpecificitySynapsin I, phospho Serine 62,67. The antibody recognizes a protein doublet of ~78 kDa corresponding to Synapsin I, phospho Serine 62,67 in lysates from rat cortex. Immunolableing is blocked by preadsorption with the phospho-peptide used as the immunogen but not by the corresponding dephospho-peptide.
Species Reactivity
  • Rat
Species Reactivity NoteThe immunogen has 100% homology with mouse and bovine.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene Symbol
  • SYN1
  • SYN1a
  • Synapsin-1
  • SYNI
  • SYN1b
Modifications
  • Phosphorylation
Purification MethodImmunoAffinity Purified
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P17600 # Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
SIZE: 705 amino acids; 74111 Da
SUBUNIT: Homodimer. Interacts with CAPON. Forms a ternary complex with NOS1 (By similarity).
SUBCELLULAR LOCATION: Cell junction, synapse.
PTM: Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE:SwissProt: P17600 # Defects in SYN1 are a cause of X-linked recessive epilepsy associated with variable learning disabilities and behavior disorders [MIM:300491].
SIMILARITY: SwissProt: P17600 ## Belongs to the synapsin family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20degC in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB9848 04053252286957

Documentation

Anti-phospho-Synapsin I (Ser62,Ser67) Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-phospho-Synapsin I (Ser62,Ser67) Antibody Certificates of Analysis

TitleLot Number
RABBIT ANTI-SYNAPSIN, phospho Serine 62,67 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2150697 2150697
RABBIT ANTI-SYNAPSIN, phospho Serine 62,67 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2386946 2386946
RABBIT ANTI-SYNAPSIN, phospho Serine 62,67 - 3547839 3547839
RABBIT ANTI-SYNAPSIN, phospho Serine 62,67 - 3888762 3888762
RABBIT ANTI-SYNAPSIN, phospho Serine 62,67 -2792924 2792924
RABBIT ANTI-SYNAPSIN, phospho Serine 62,67 AFFINITY PURIFIED - 2095320 2095320
RABBIT ANTI-SYNAPSIN, phospho Serine 62,67 AFFINITY PURIFIED POLYCLONAL ANTIBODY 3152212
RABBIT ANTI-SYNAPSIN, phospho Serine 62,67 AFFINITY PURIFIED POLYCLONAL ANTIBODY 3103804
RABBIT ANTI-SYNAPSIN, phospho Serine 62,67 AFFINITY PURIFIED POLYCLONAL ANTIBODY 2930470
RABBIT ANTI-SYNAPSIN, phospho Serine 62,67 AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2092609 2092609
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Brochure

Title
Pathways and Biomarkers of Glutamatergic Synapse Flyer

Data Sheet

Title
RABBIT ANTI-SYNAPSIN, phospho Serine 62,67 AFFINITY PURIFIED

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Categories

Life Science Research > Antibodies and Assays > Primary Antibodies