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MABC532 Anti-PTHrP Antibody, clone 4C4.1

Detect PTHLH using this mouse monoclonal Anti-PTHrP Antibody, clone 4C4.1, Cat. No. MABC532, validated for use in Western Blotting.

Anti-PTHrP Antibody, clone 4C4.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: PTHRP, PTHLH UniProt Number: P12272
MABC532
100 μg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC532
DescriptionAnti-PTHrP Antibody, clone 4C4.1
Alternate Names
  • Parathyroid hormone-related protein
  • PTHrP
  • PTH-rP
  • Parathyroid hormone-like protein
  • PLP
Background InformationParathyroid hormone-related protein (UniProt P12272; also known as Parathyroid hormone-like related protein, Parathyroid hormone-like hormone preproprotein, PLP, PTH-related protein, PTH-rP, PTHrP) is encoded by the PTHLH (also known as BDE2, HHM, PTHR, PTHRP) gene (Entrez Gene ID 5744) in human. Parathyroid hormone-related protein is initially translated as a 177 amino acid preproprotein with an N-terminal signal sequence (aa 1-24) and a propeptide sequence (aa 25-34), which are later removed to yield the mature protein. The mature protein is further cleaved to produce PTHrP[1-34] (aa 37-70), PTHrP[1-36] (aa 37-72), PTHrP[38-94] (aa 74-130), and PTHrP[107-139] (aa 143-175; also known as Osteostatin). PTHrP is produced in a wide variety of tissues, where it acts as a paracrine or autocrine factor to regulate cellular and organ growth, development, migration, differentiation, calcium transport, survival and apoptosis.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect PTHLH using this mouse monoclonal Anti-PTHrP Antibody, clone 4C4.1, Cat. No. MABC532, validated for use in Western Blotting.
Key Applications
  • Western Blotting
Biological Information
ImmunogenGST-tagged recombinant human PTHrP lacking signal and propeptide sequence.
Clone4C4.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • PTHRP
  • PTHLH
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~16/6 kDa observed. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in MCF-7 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected PTHrP in 10 µg of MCF-7 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABC532 04055977177039

Documentation

Anti-PTHrP Antibody, clone 4C4.1 SDS

Title

Safety Data Sheet (SDS) 

Anti-PTHrP Antibody, clone 4C4.1 Certificates of Analysis

TitleLot Number
Anti-PTHrP, clone 4C4.1 - 3590793 3590793
Anti-PTHrP, clone 4C4.1 - 3900419 3900419
Anti-PTHrP, clone 4C4.1 - 4080140 4080140
Anti-PTHrP, clone 4C4.1 -Q2583333 Q2583333
Anti-PTHrP, clone 4C4.1 Monoclonal Antibody 3792040

Technical Info

Title
Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
White Paper: Further considerations of antibody validation and usage.