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ABN465 Anti-PICALM Antibody

Anti-PICALM Antibody is a highly specific rabbit polyclonal antibody, that targets Phosphatidylinositol-binding clathrin assembly protein & has been tested in western blotting.

Anti-PICALM Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: PICALM UniProt Number: Q13492
ABN465
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
MWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN465
DescriptionAnti-PICALM Antibody
Alternate Names
  • Phosphatidylinositol-binding clathrin assembly protein
  • LAP
  • CALM
  • CLTH
  • Clathrin assembly lymphoid myeloid leukemia protein
Background InformationPhosphatidylinositol-binding clathrin assembly protein (PICALM), also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area as a component of the coated pit internalization machinery. PICALM fusion proteins have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia, and chromosomal aberrations are found in diffuse histiocytic lymphomas. PICALM is also expressed in neuronal synapses where it facilitates the endocytosis of VAMP2. PICALM variants are associated with Alzheimer's disease and are thought to be involved in the endocytosis and recycling of the amyloid protein precursor (APP).
References
Product Information
FormatAffinity Purified
Control
  • EL4 cell lysate
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-PICALM Antibody is a highly specific rabbit polyclonal antibody, that targets Phosphatidylinositol-binding clathrin assembly protein & has been tested in western blotting.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human PICALM.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody can recognize all isoforms of PICALM.
Species Reactivity
  • Mouse
Species Reactivity NoteDemonstrated to react with Mouse. Predicted to react with Human based on immunogen design.
Antibody TypePolyclonal Antibody
Gene Symbol
  • PICALM
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~62 kDa and ~71 kDa observed. Uncharacterized bands may appear in some lysate(s). Uniprot describes 5 isoforms between ~60 kDa and ~71 kDa.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in EL4 cell lysate.

Western Blotting Analysis: 1 µg/mL of this antibody detected PICALM in 15 µg of EL4 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABN465 04053252909993