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MABN2186 Anti-DPP6 Antibody, clone 7G1.1

Anti-DPP6 antibody, clone 7G1.1, Cat. No. MABN2186, is a highly specific mouse monoclonal antibody that targets DPP6 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-DPP6 Antibody, clone 7G1.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: DPP6 UniProt Number: P42658
MABN2186
100 μg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
M, H, RIH(P), WBMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN2186
DescriptionAnti-DPP6 Antibody, clone 7G1.1
Alternate Names
  • Dipeptidyl aminopeptidase-like protein 6
  • DPPX
  • Dipeptidyl aminopeptidase-related protein
  • Dipeptidyl peptidase 6
  • Dipeptidyl peptidase IV-like protein
  • Dipeptidyl peptidase VI
  • DPP VI
Background InformationDipeptidyl aminopeptidase-like protein 6 (UniProt: P42658; also known as DPPX, Dipeptidyl aminopeptidase-related protein, Dipeptidyl peptidase 6, Dipeptidyl peptidase IV-like protein, Dipeptidyl peptidase VI, DPP VI) is encoded by the DPP6 gene (Gene ID: 1804) in human. DPP6 is a type II membrane glycoprotein of the dipeptydilaminopeptidase-like proteins (DPPLs) subfamily. DPP6 has a short cytoplasmic domain, a long extracellular domain and a transmembrane domain. DPP6 is an inactive protease homolog that is an important regulator of CG cell excitability. It is widely expressed in the brain where it co-assembles with KCND2 channels and KChIP auxiliary subunits to regulate the amplitude and functional properties of the somatodendritic A-current, ISA. DPP6 is reported to promote cell surface expression of KCND2 and modulates it s the activity and gating characteristics. Defects in DPP6 gene have been linked to familial paroxysmal ventricular fibrillation 2, which is characterized by cardiac arrhythmia marked by fibrillary ventricular muscle contractions. In addition, DPP6 mutations are reported to cause mental retardation, autosomal dominant 33 (MRD33) characterized by mental retardation associated with microcephaly and impairments in adaptive behavior.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-DPP6 antibody, clone 7G1.1, Cat. No. MABN2186, is a highly specific mouse monoclonal antibody that targets DPP6 and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
Key Applications
  • Immunohistochemistry (Paraffin)
  • Western Blotting
Application NotesWestern Blotting Analysis: 0.5 µg/mL from a representative lot detected DPP6 in 10 µg of human fetal brain tissue lysate.

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected DPP6 in human cerebral cortex, human cerebellum, rat cerebral cortex, and rat cerebellum tissue.
Biological Information
ImmunogenGST-tagged recombinant fragement corresponding to 72 amino acids from the N-terminal half of human DPP6.
Clone7G1.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone 7G1.1 detected DPP6 in mouse brain.
IsotypeIgG1κ
Species Reactivity
  • Mouse
  • Human
  • Rat
Species Reactivity NoteHuman, Mouse, Rat.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • DPP6
Purification MethodProtein G purified
UniProt Number
Molecular Weight~100 kDa observed; 97.59 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected DPP6 in 10 µg of mouse brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABN2186 04054839156007