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06-1287 Anti-DAI Antibody

Detect DAI using this Anti-DAI Antibody validated for use in WB.

Anti-DAI Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunological Signaling Gene Symbol: DLM1, DLM-1, DAI, ZBP1 UniProt Number: Q9QY24
06-1287
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
MWBRbPurifiedPolyclonal Antibody
Description
Catalogue Number06-1287
DescriptionAnti-DAI Antibody
Alternate Names
  • Z-DNA binding protein 1
  • chromosome 20 open reading frame 183
  • DNA-dependent activator of IRFs
  • DNA-dependent activator of interferon regulatory factors
  • Tumor stroma and activated macrophage protein DLM-1
Background InformationDNA-dependent activator of IFN regulatory factors (DAI), also known as DLM-1/ZBP1, belongs to the Zipcode-binding protein (ZBP) family. This family of proteins regulate the stability and localization of their target mRNA. It is expressed during embryonic development, but repressed in normal adult tissue. When re-activated, it has been detected in tumors such as breast, colon, and non-small cell carcinomas.
References
Product Information
FormatPurified
Control
  • LPS-treated (positive control) and untreated (negative control) RAW264.7 cell lysate
PresentationPurified rabbit polyclonal in PBS with 0.05% sodium azide.
Applications
ApplicationDetect DAI using this Anti-DAI Antibody validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenRecombinant protein corresponding to mouse DAI.
EpitopeUnknown
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes DAI.
Species Reactivity
  • Mouse
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • DLM1
  • DLM-1
  • DAI
  • ZBP1
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFUNCTION: May play a role in host defense against tumors and pathogens. Binds Z-DNA.

TISSUE SPECIFICITY: Expressed in lung, spleen and liver. Lower levels were seen in heart, kidney and testis. Expression is greatly up-regulated in tumor stromal cells and activated macrophages.

INDUCTION: By interferon gamma and lipopolysaccharides (LPS).

SEQUENCE SIMLARITIES: Contains 2 DRADA repeats.
Molecular Weight~55 kDa observed.
A non-specific bands may be observed at ~70 & 35 kDa (Karayel, E., et al. (2009). Eur. J. Immunol. 39:1–8).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in LPS untreated and treated RAW264.7 cell lysate.

Western Blot Analysis: A 1:1,000 dilution of this antibody was used in 10 µg of LPS-treated (positive control) and untreated (negative control) RAW264.7 cell lysate for the purpose of detecting DAI.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
06-1287 04053252628825

Documentation

Anti-DAI Antibody Certificates of Analysis

TitleLot Number
Anti-DAI - NRG1747052 NRG1747052