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MABF509 Anti-CD115 (c-fms) Antibody (mouse), PE, clone AFS98

This rat monoclonal antibody Anti-CD115 (c-fms) (mouse), PE, clone AFS98 validated for use in western blotting & Flow Cytometry for the detection of CD115 (c-fms).

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Research Category: Inflammation & Immunology Gene Symbol: Csf1r, Csfmr, Fms UniProt Number: P09581
MABF509
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
MFC, WBRPEMonoclonal Antibody
Description
Catalogue NumberMABF509
DescriptionAnti-CD115 (c-fms) Antibody (mouse), PE, clone AFS98
Alternate Names
  • Macrophage colony-stimulating factor 1 receptor
  • CSF-1 receptor
  • CSF-1-R
  • CSF-1R
  • M-CSF-R
  • Proto-oncogene c-Fms
  • CD115
  • CSF1-R
Background InformationThe AFS98 antibody is specific for mouse CD115, also known as Colony-Stimulating Factor-1 Receptor (CSF-1R), a 145 kDa receptor from the PDGF receptor family. Receptor activation by the ligands IL-34 or CSF-1 (M-CSF) occurs via homodimerization of CD115 and subsequent tyrosine phosphorylation and ubiquitination of intracellular domains. CD115 signaling promotes differentiation of myeloid precursors, as well as the continued regulation of proliferation, survival and function of mononuclear phagocytes, dendritic cells and osteoclasts. While IL-34 and CSF-1 may induce similar cellular responses, they are differentially expressed and as such exert complimentary actions via CD115.The AFS98 antibody may be used for identification of myeloid lineage cells by flow cytometry, and is commonly used for in vivo or in vitro neutralization of CSF-1 Receptor.
References
Product Information
FormatPE
PresentationPurified Rat Monoclonal Antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis rat monoclonal antibody Anti-CD115 (c-fms) (mouse), PE, clone AFS98 validated for use in western blotting & Flow Cytometry for the detection of CD115 (c-fms).
Key Applications
  • Flow Cytometry
  • Western Blotting
Biological Information
ImmunogenImmunogen information for this antibody is proprietary information.
CloneAFS98
Concentration0.2 mg/mL
HostRat
IsotypeIgG2aκ
Species Reactivity
  • Mouse
Antibody TypeMonoclonal Antibody
Gene Symbol
  • Csf1r
  • Csfmr
  • Fms
Purification MethodSize Exclusion Chromatography
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceThe monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

Flow Cytometry Analysis: 0.125 µg of this antibody detected CD115 (c-fms) in one million C57Bl/6 peripheral blood cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsIt is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABF509 04053252979347