Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

MABC523 Anti-BCL7A Antibody, clone 15C

Anti-BCL7A Antibody, clone 15C is a highly specific mouse monoclonal antibody, that targets B-cell CLL/lymphoma 7 protein family member A & has been tested in IHC & Immunofluorescence.

Anti-BCL7A Antibody, clone 15C MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Cell Cycle, DNA Replication & Repair Gene Symbol: BCL7A UniProt Number: Q4VC05
MABC523
100 µg  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HIHC, IFMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABC523
DescriptionAnti-BCL7A Antibody, clone 15C
Alternate Names
  • B-cell CLL/lymphoma 7 protein family member A
Background InformationThe protein named B-cell CLL/lymphoma 7 protein family member A or BCL7A and encoded by the human gene named BCL7A is protein that interacts with SWI/SNF components (a nucleosome remodeling complex), implicating that BCL7A’s normal function involves chromatin remodeling. BCL7A was original cloned from a chromosomal translocation in a Burkitt lymphoma cell line and appears to be important in B cell malignancy. Overexpression of BCL7A is associated with germinal center phenotype formation in B cells and BCL7A expression is up regulated in CLL and multiple myeloma but lower in mycosis fungoides and peripheral T cell lymphoma. Recent research indicates that BCL7A was expressed at the pro B and T cell stage and persisted through the pre-B and mature B cell stages. BCL7A expression was maintained in late B cell differentiation but down-regulated in late plasma cells and mature T cells. In haematological malignancies, BCL7A protein was present in the majority of precursor and mature B cell lymphomas with increased expression amongst GC-related lymphomas. Mature T cell malignancies did not express BCL7A.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-BCL7A Antibody, clone 15C is a highly specific mouse monoclonal antibody, that targets B-cell CLL/lymphoma 7 protein family member A & has been tested in IHC & Immunofluorescence.
Key Applications
  • Immunohistochemistry
  • Immunofluorescence
Application NotesImmunofluorescence Analysis: A 1:10 dilution from a representative lot detected BCL7A in human tonsil tissue (Prof. G. Roncador, CNIO, Madrid).

Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected BCL7A in human lymph node, spleen, and thymus tissue (Prof. G. Roncador, CNIO, Madrid).

Immunohistochemistry Analysis: A representative lot detected BCL7A in HEK293 cells transfected with BCL7A, and not in HEK293 cells transfected with SPIB protein (Prof. G. Roncador, CNIO, Madrid).
Biological Information
ImmunogenHis-tagged recombinant protein corresponding to human BCL7A.
Clone15C
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • BCL7A
Purification MethodProtein G Purified
UniProt Number
Molecular Weight23 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in human tonsil and colon tissues.

Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected BCL7A in human tonsil and colon tissues.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABC523 04053252934940

Documentation

Anti-BCL7A Antibody, clone 15C SDS

Title

Safety Data Sheet (SDS) 

Anti-BCL7A Antibody, clone 15C Certificates of Analysis

TitleLot Number
Anti-BCL7A, clone 15C - 3272813 3272813
Anti-BCL7A, clone 15C - 3448840 3448840
Anti-BCL7A, clone 15C - 3600557 3600557
Anti-BCL7A, clone 15C - 3836459 3836459
Anti-BCL7A, clone 15C - 4237264 4237264
Anti-BCL7A, clone 15C - Q2303827 Q2303827

References

Reference overviewPub Med ID
British journal of haematology
Ramos-Medina, R; Montes-Moreno, S; Maestre, L; Cañamero, M; Rodríguez-Pinilla, M; Martínez-Torrecuadrada, J; Piris, MÁ; Majid, A; Dyer, MJ; Pulford, K; Roncador, G
British journal of haematology  160  106-9  2013

23043359 23043359

Brochure

Title
New Products Flyer- Feb 2014 - Vol 1