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126870 Alsterpaullone - CAS 237430-03-4 - Calbiochem

A cell-permeable, potent, reversible, and ATP competitive inhibitor of GSK-3β (IC₅₀ = 4 nM) and Cdk1/cyclin B (IC₅₀ = 35 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 9-Nitropaullone, NSC 705701

Primary Target: GSK-3β, Cdk1/cyclin B
126870
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
237430-03-4C₁₆H₁₁N₃O₃

Products

Catalogue NumberPackaging Qty/Pack
126870-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable, potent, reversible, and ATP competitive inhibitor of GSK-3β (IC50 = 4 nM) and Cdk1/cyclin B (IC50 = 35 nM). Displays remarkable in vitro antitumor activity. Inhibits Tau phosphorylation at sites that are typically phosphorylated by GSK-3β in Alzheimer’s disease. Also inhibits Cdk5/p25-dependent phosphorylation of DARPP-32.
Catalogue Number126870
Brand Family Calbiochem®
Synonyms9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 9-Nitropaullone, NSC 705701
References
ReferencesLeost, M., et al. 2000. Eur. J. Biochem. 267, 5983.
Schultz, C., et al. 1999. J. Med. Chem. 42, 2909.
Product Information
CAS number237430-03-4
ATP CompetitiveY
FormLight yellow to brown solid
Hill FormulaC₁₆H₁₁N₃O₃
Chemical formulaC₁₆H₁₁N₃O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGSK-3β, Cdk1/cyclin B
Primary Target IC<sub>50</sub>4 nM, 35 nM, against GSK-3β, Cdk1/cyclin B, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
126870-1MG 04055977222159

Documentation

Alsterpaullone - CAS 237430-03-4 - Calbiochem Certificates of Analysis

TitleLot Number
126870

References

Reference overview
Leost, M., et al. 2000. Eur. J. Biochem. 267, 5983.
Schultz, C., et al. 1999. J. Med. Chem. 42, 2909.

Brochure

Title
Alzheimer's Disease Brochure & Technical Guide
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-June-2019 JSW
Synonyms9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one, 9-Nitropaullone, NSC 705701
DescriptionA cell-permeable, potent, reversible, and ATP competitive inhibitor of cdk1/cyclin B (IC50 = 35 nM) and GSK-3β (IC50 = 4 nM). One of the most active paullones that acts by competing with ATP for binding to GSK-3β and inhibits the phosphorylation of tau. Also inhibits the activity of Cdk5/p25-dependent phosphorylation of DARPP-32 (a 32 kDa dopamine and adenosine 3',5'-monophosphate-regulated phosphoprotein). Displays remarkable antitumor activity in vitro. Inhibits growth of the colon cancer cell line HCT-116, with an IC50 in the nanomolar range.
FormLight yellow to brown solid
Intert gas (Yes/No) Packaged under inert gas
CAS number237430-03-4
Chemical formulaC₁₆H₁₁N₃O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (20 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLeost, M., et al. 2000. Eur. J. Biochem. 267, 5983.
Schultz, C., et al. 1999. J. Med. Chem. 42, 2909.