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116816 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem

A potent, cell-permeable, and reversible metabolically-stable cAMP antagonist that inhibits cAMP-dependent protein kinase and shows preference for PKA type I.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Rp-8-Br-cAMPS, Na, PKA Inhibitor VI

Primary Target: PKA 1
116816
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₀H₁₀BrN₅O₅PS · Na

Products

Catalogue NumberPackaging Qty/Pack
116816-5UMOL Plastic ampoule 5 umol
Description
OverviewA potent, cell-permeable, and reversible metabolically-stable cAMP antagonist that inhibits cAMP-dependent protein kinase and shows preference for PKA type I. More lipophilic than cAMP antagonist Rp-cAMPS (Cat. No. 116814).
Note: 5 µmol = 2.23 mg.
Catalogue Number116816
Brand Family Calbiochem®
SynonymsRp-8-Br-cAMPS, Na, PKA Inhibitor VI
References
ReferencesCalaghan, S.C., et al. 1999. Pflugers Arch. 437, 780.
Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
Dostmann, W.R. et al. 1990. J. Biol. Chem. 265, 10484.
Product Information
ATP CompetitiveN
DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
FormLyophilized
Hill FormulaC₁₀H₁₀BrN₅O₅PS · Na
Chemical formulaC₁₀H₁₀BrN₅O₅PS · Na
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKA 1
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
116816-5UMOL 04055977208269

Documentation

Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem Certificates of Analysis

TitleLot Number
116816

References

Reference overview
Calaghan, S.C., et al. 1999. Pflugers Arch. 437, 780.
Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
Dostmann, W.R. et al. 1990. J. Biol. Chem. 265, 10484.

Brochure

Title
Inhibitor Sourcebook 3rd Edition

Citations

Title
  • Ralf Gutzmer, et al. (2005) Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. Journal of Immunology 5224-5232.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision08-January-2010 RFH
    SynonymsRp-8-Br-cAMPS, Na, PKA Inhibitor VI
    DescriptionCell-permeable, potent, reversible, and metabolically stable antagonist of cAMP that is resistant to the action of mammalian cyclic nucleotide phosphodiesterases. Rp-8-Br-cAMPS is more lipophilic as compared to 8-Br-cAMP and Rp-cAMPS. In contrast to other common ATP-site inhibitors or to its parent compound Rp-cAMPS, Rp-8-Br-cAMPS discriminates between both isozymes of protein kinase A, preferring type I, thus providing additional selectivity. By occupying cAMP binding sites, prevents dissociation and activation of the kinase holoenzyme. λ = 264 nm (H2O, pH 7.0); εmax 17,000 M-1cm-1.
    FormLyophilized
    Chemical formulaC₁₀H₁₀BrN₅O₅PS · Na
    Structure formulaStructure formula
    Purity≥99% by HPLC
    SolubilityH₂O (40 mg/ml)
    Storage -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Standard Handling
    ReferencesCalaghan, S.C., et al. 1999. Pflugers Arch. 437, 780.
    Gjertsen, B.T., et al. 1995. J. Biol. Chem. 270, 20599.
    Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
    Dostmann, W.R. et al. 1990. J. Biol. Chem. 265, 10484.
    Citation
  • Ralf Gutzmer, et al. (2005) Histamine H4 receptor stimulation suppresses IL-12p70 production and mediates chemotaxis in human monocyte-derived dendritic cells. Journal of Immunology 5224-5232.
    		•