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114802 AdaAhx₃L₃VS - CAS 389064-25-9 - Calbiochem

A potent, covalent, cell-permeable, irreversible inhibitor of chymotrypsin-like (50-100 nM), trypsin-like (1-5 µM), and PGPH (0.5-1 µM) activities of the 20S proteasome.

AdaAhx₃L₃VS - CAS 389064-25-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Adamantane-acetyl-(6-aminohexanoyl)₃-(leucinyl)₃-vinyl-(methyl)-sulfone, Proteasome Inhibitor XVI

Primary Target: chymotrypsin-like activity of the 20S proteasome
114802
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
389064-25-9C₅₀H₈₈N₆O₈S

Products

Catalogue NumberPackaging Qty/Pack
114802-250UG Plastic ampoule 250 μg
Description
OverviewA potent, covalent, cell-permeable, irreversible inhibitor of chymotrypsin-like (50-100 nM), trypsin-like (1-5 µM), and PGPH (0.5-1 µM) activities of the 20S proteasome.
Catalogue Number114802
Brand Family Calbiochem®
SynonymsAdamantane-acetyl-(6-aminohexanoyl)₃-(leucinyl)₃-vinyl-(methyl)-sulfone, Proteasome Inhibitor XVI
References
ReferencesKessler, B.M., et al. 2001. Chem. Biol. 8, 913.
Product Information
CAS number389064-25-9
ATP CompetitiveN
FormOff-white powder
Hill FormulaC₅₀H₈₈N₆O₈S
Chemical formulaC₅₀H₈₈N₆O₈S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetchymotrypsin-like activity of the 20S proteasome
Primary Target IC<sub>50</sub>50-100 nM against chymotrypsin-like activity of the 20S proteasome
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
114802-250UG 04055977208108

Documentation

AdaAhx₃L₃VS - CAS 389064-25-9 - Calbiochem Certificates of Analysis

TitleLot Number
114802

References

Reference overview
Kessler, B.M., et al. 2001. Chem. Biol. 8, 913.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-October-2007 RFH
SynonymsAdamantane-acetyl-(6-aminohexanoyl)₃-(leucinyl)₃-vinyl-(methyl)-sulfone, Proteasome Inhibitor XVI
DescriptionA cell-permeable, peptide vinyl sulfone that acts as a potent, irreversible inhibitor of proteasome activity. Covalently modifies the catalytically active β-subunits of the proteasome. Shown to inhibit the chymotrypsin-like (10-50 nM), trypsin-like (1-5 µM), and the peptidyl glutamyl peptide hydrolyzing (PGPH) (0.5-1 µM) activities of purified 20S proteasomes from rabbit muscle. Inhibits proteasomal degradation of deglycosylated MHC HLA-A2 heavy chain in US11+ cells (~50 µM).
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
CAS number389064-25-9
Chemical formulaC₅₀H₈₈N₆O₈S
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKessler, B.M., et al. 2001. Chem. Biol. 8, 913.