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123855 AKR1C3 Inhibitor - CAS 1284180-11-5 - Calbiochem

The AKR1C3 Inhibitor controls the biological activity of AKR1C3.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(4-(Trifluoromethyl)phenylamino)benzoic acid

123855
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1284180-11-5C₁₄H₁₀F₃NO₂

Products

Catalogue NumberPackaging Qty/Pack
123855-25MG Glass bottle 25 mg
Description
OverviewA cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) (IC50 = 60 nM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 22.7, 15.4, 62.7, >50, and >50 µM for and AKR1C1, AKR1C2, AKR1C4, AKR1B1 and AKR1B10, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100 µM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells (~10 µM).
Catalogue Number123855
Brand Family Calbiochem®
Synonyms3-(4-(Trifluoromethyl)phenylamino)benzoic acid
References
ReferencesAdeniji, A.O., et al. 2012. J. Med. Chem. 55, 2311.
Adeniji, A.O., et al. 2011. Bioorg. Med. Chem. Lett. 21,1464.
Product Information
CAS number1284180-11-5
FormWhite powder
Hill FormulaC₁₄H₁₀F₃NO₂
Chemical formulaC₁₄H₁₀F₃NO₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
123855-25MG 04055977206302

Documentation

AKR1C3 Inhibitor - CAS 1284180-11-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

AKR1C3 Inhibitor - CAS 1284180-11-5 - Calbiochem Certificates of Analysis

TitleLot Number
123855

References

Reference overview
Adeniji, A.O., et al. 2012. J. Med. Chem. 55, 2311.
Adeniji, A.O., et al. 2011. Bioorg. Med. Chem. Lett. 21,1464.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-July-2012 JSW
Synonyms3-(4-(Trifluoromethyl)phenylamino)benzoic acid
DescriptionA cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) (IC50 = 60 nM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 22.7, 15.4, 62.7, >50, and >50 µM for and AKR1C1, AKR1C2, AKR1C4, AKR1B1 and AKR1B10, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100 µM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells (~10 µM).
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number1284180-11-5
Chemical formulaC₁₄H₁₀F₃NO₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesAdeniji, A.O., et al. 2012. J. Med. Chem. 55, 2311.
Adeniji, A.O., et al. 2011. Bioorg. Med. Chem. Lett. 21,1464.