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385581 11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem

The 11beta-HSD1 Inhibitor, 10j, also referenced under CAS 1009373-58-3, controls the biological activity of 11beta-HSD1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
385581
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1009373-58-3C₂₆H₃₃BrN₂O₃

Products

Catalogue NumberPackaging Qty/Pack
385581-10MG 10 mg
Description
OverviewA cell permeable, spirocyclic urea that acts as a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) (IC50 of 1.6 nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11β-HSD1 activity in the presence of 10j2 (10mg/kg in animals p.o.) results in an ˜ 80% reduction in the concentration of plasma cortisol over vehicle treated controls.
Catalogue Number385581
Brand Family Calbiochem®
References
ReferencesTice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.
Product Information
CAS number1009373-58-3
FormWhite solid
Hill FormulaC₂₆H₃₃BrN₂O₃
Chemical formulaC₂₆H₃₃BrN₂O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
385581-10MG 04055977190298

Documentation

11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem Certificates of Analysis

TitleLot Number
385581

References

Reference overview
Tice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
DescriptionA cell permeable, spirocyclic urea that acts as a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) (IC50 of 1.6 nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11β-HSD1 activity in the presence of 10j2 (10 mg/kg in animals p.o.) results in an ~80% reduction in the concentration of plasma cortisol over vehicle treated controls.
FormWhite solid
CAS number1009373-58-3
Chemical formulaC₂₆H₃₃BrN₂O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSL (100 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesTice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.