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203694 bpV(bipy) - Calbiochem

A potent inhibitor of phosphotyrosine phosphatase (Ki = 100 nM for insulin receptor dephosphorylation).

bpV(bipy) - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Potassium Bisperoxo(bipyridine)oxovanadate (V), PTEN Inhibitor II, PTP Inhibitors XIV

Primary Target: phosphotyrosine phosphatase
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203694
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Overview

Replacement Information

Key Spec Table

Empirical Formula
K[VO(O₂)₂C₁₀H₈N₂] · 3H₂O

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203694-5MG
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      Description
      OverviewA potent inhibitor of phosphotyrosine phosphatase (Ki = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC50 = 18 nM).
      Catalogue Number203694
      Brand Family Calbiochem®
      SynonymsPotassium Bisperoxo(bipyridine)oxovanadate (V), PTEN Inhibitor II, PTP Inhibitors XIV
      References
      ReferencesSchmid, A.C., et al. 2004. FEBS Lett. 566, 35.
      Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.
      Product Information
      ATP CompetitiveN
      FormYellow to orange solid
      Hill FormulaK[VO(O₂)₂C₁₀H₈N₂] · 3H₂O
      Chemical formulaK[VO(O₂)₂C₁₀H₈N₂] · 3H₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetphosphotyrosine phosphatase
      Primary Target IC<sub>50</sub>18 nM against PTEN
      Primary Target K<sub>i</sub>100 nM for phosphotyrosine phosphatase
      Purity≥95% by ⁵¹V-NMR
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      203694-5MG 04055977204414

      Documentation

      bpV(bipy) - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      bpV(bipy) - Calbiochem Certificates of Analysis

      TitleLot Number
      203694

      References

      Reference overview
      Schmid, A.C., et al. 2004. FEBS Lett. 566, 35.
      Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.

      Brochure

      Title
      Protein Phosphatases Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-May-2008 RFH
      SynonymsPotassium Bisperoxo(bipyridine)oxovanadate (V), PTEN Inhibitor II, PTP Inhibitors XIV
      DescriptionA potent inhibitor of phosphotyrosine phosphatase activity (Ki = 100 nM for insulin receptor dephosphorylation). An activator of insulin receptor kinase (IRK). Also reported to be a potent inhibitor of PTEN (IC50 = 18 nM).
      FormYellow to orange solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaK[VO(O₂)₂C₁₀H₈N₂] · 3H₂O
      Structure formulaStructure formula
      Purity≥95% by ⁵¹V-NMR
      SolubilityH₂O (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in solution; reconstitute just prior to use.
      Toxicity Harmful
      ReferencesSchmid, A.C., et al. 2004. FEBS Lett. 566, 35.
      Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596.