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23-027M b-catenin Protein, activated, 250 µg

Activated, full length, recombinant human β-catenin. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using GSK-3a. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.

Key Applications: Enzyme Assays
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23-027M
250 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Key ApplicationsSpeciesCascade Component
      Enzyme AssaysHuman Substrate
      Description
      Catalogue Number23-027M
      Brand Family Upstate
      Trade Name
      • Upstate
      Descriptionb-catenin Protein, activated, 250 µg
      OverviewAXIS Axon Isolation Devices - culture dish mounted, 150 µm long channels, 5 devices
      Alternate Names
      • Catenin beta-1
      Background Informationβ-catenin is a multifunctional protein; it is a central component of the cadherin cell adhesion complex, regulating the control of cell adhesion and plays an essential role in the Wingless/Wnt signaling pathway that governs cell fate in early embryogenesis. The regulation of β-catenin turnover in the cells is governed by its phosphorylation status which allows the targeting of ubiquitin-dependent proteolysis. Altered levels of protein expression as well as genetic mutations of β-catenin have been implicated in a number of human cancers.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActivated, full length, recombinant human β-catenin. N-terminal c-Myc, 6His-tagged. Phosphorylated in vitro using GSK-3a. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.
      Key Applications
      • Enzyme Assays
      Biological Information
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Cascade ComponentSubstrate
      Entrez Gene Number
      Purification MethodPurified using immobilized metal affinity chromatography.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size250 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      23-027M 04053252294433

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      23-027 b-catenin Protein, activated, 10 µg Show Pricing & Availability

      Product Families

      Ubiquitin Proteasome System: Enzymes and Substrates

      Millipore has removed the complexity of Ubiquitination by providing functionally validated enzymes and substrates, making the pathway readily accessible for research and drug discovery.
      Learn More >>

      Categories

      Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitination Substrates
      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Ubiquitination Substrates