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682160 Xestospongin C, Xestospongia sp. - Calbiochem

Overview

Key Spec Table

Empirical Formula
C₂₈H₅₀N₂O₂

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      Description
      OverviewAn oxaquinolizidine alkaloid isolated from a marine sponge. A very potent, reversible, and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM) that does not interact with the IP3-binding site. Displays high selectivity over the skeletal isoform of the ryanodine receptor type 1 (RyR-1). Also blocks bradykinin- and carbamylcholine-induced Ca2+ efflux from the endoplasmic reticulum stores in a reversible manner.
      Catalogue Number682160
      Brand Family Calbiochem®
      SynonymsXeC
      References
      ReferencesOka, T., et al. 2002. Br. J. Pharmacol. 135, 1959.
      Gafni, J., et al. 1997. Neuron 19, 723.
      Tinker, A., and Williams, A.J. 1995. Biophys. J. 68, 111.
      Callaway, C., et al. 1994. J. Biol. Chem. 269, 15876.
      Quirion, J.C., et al. 1992. J. Nat. Prod. 55, 1505.
      Nakagawa, M., et al. 1984. Tetrahedron Lett. 25, 3227.
      Product Information
      ATP CompetitiveN
      FormWhite to off-white film
      Hill FormulaC₂₈H₅₀N₂O₂
      Chemical formulaC₂₈H₅₀N₂O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationXestospongin C, Xestospongia sp. CAS 88903-69-9, is a highly potent, reversible, and membrane-permeable blocker of IP3-mediated Ca2+ release (IC50 = 358 nM).
      Biological Information
      Primary TargetIP3-mediated Ca2+ release
      Primary Target IC<sub>50</sub>358 nM in blocking IP3-mediated Ca2+ release
      Purity≥98% by TLC or HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-24/25-36/37/39-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      682160-10UG 07790788052355