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681625 W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 240 µM).

W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl

Primary Target: Myosin light chain kinase (Mlck)
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681625
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
61714-25-8C₁₆H₂₂N₂O₂S · HCl

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      Description
      OverviewA cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM).
      Catalogue Number681625
      Brand Family Calbiochem®
      SynonymsN-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl
      References
      ReferencesTanaka, T., et al. 1983. Pharmacol. 26, 249.
      Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
      Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
      Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
      Product Information
      CAS number61714-25-8
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaC₁₆H₂₂N₂O₂S · HCl
      Chemical formulaC₁₆H₂₂N₂O₂S · HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMyosin light chain kinase (Mlck)
      Primary Target IC<sub>50</sub>230 µM and 240 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.
      Purity≥98% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      681625-1MG 04055977260137

      Documentation

      W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem Certificates of Analysis

      TitleLot Number
      681625

      References

      Reference overview
      Tanaka, T., et al. 1983. Pharmacol. 26, 249.
      Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
      Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
      Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-January-2010 RFH
      SynonymsN-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl
      DescriptionA cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM) and myosin light chain kinase (IC50 = 230 µM).
      FormCrystalline solid
      CAS number61714-25-8
      Chemical formulaC₁₆H₂₂N₂O₂S · HCl
      Structure formulaStructure formula
      Purity≥98% by NMR
      SolubilityDMSO or H₂O
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Toxicity Standard Handling
      ReferencesTanaka, T., et al. 1983. Pharmacol. 26, 249.
      Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
      Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
      Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

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      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors