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681625
Sigma-AldrichW-5, Hydrochloride - CAS 61714-25-8 - Calbiochem
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 240 µM).
More>>A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 240 µM). Less<<
W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM).
Catalogue Number
681625
Brand Family
Calbiochem®
Synonyms
N-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl
References
References
Tanaka, T., et al. 1983. Pharmacol.26, 249. Asano, M., et al. 1982. J. Pharmacol. Exp. Ther.220, 191. Hidaka, H. 1981. Prot. Nuc. Acid Enz.26, 977. Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem.255, 11078.
W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem Certificates of Analysis
Title
Lot Number
681625
References
Reference overview
Tanaka, T., et al. 1983. Pharmacol.26, 249. Asano, M., et al. 1982. J. Pharmacol. Exp. Ther.220, 191. Hidaka, H. 1981. Prot. Nuc. Acid Enz.26, 977. Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem.255, 11078.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
Revision
06-January-2010 RFH
Synonyms
N-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl
Description
A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM) and myosin light chain kinase (IC50 = 230 µM).
Form
Crystalline solid
CAS number
61714-25-8
Chemical formula
C₁₆H₂₂N₂O₂S · HCl
Structure formula
Purity
≥98% by NMR
Solubility
DMSO or H₂O
Storage
Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity
Standard Handling
References
Tanaka, T., et al. 1983. Pharmacol.26, 249. Asano, M., et al. 1982. J. Pharmacol. Exp. Ther.220, 191. Hidaka, H. 1981. Prot. Nuc. Acid Enz.26, 977. Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem.255, 11078.
