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673000 Vacuolin-1 - CAS 351986-85-1 - Calbiochem

A cell-permeable triazine based compound that inhibits Ca2+-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content, without affecting enlargeosomes or other membrane-bound organelles.

Vacuolin-1 - CAS 351986-85-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Ca2+-dependent fusion of lysosomes with the plasma membrane
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673000
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
351986-85-1C₂₆H₂₄IN₇O

Pricing & Availability

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673000-10MG
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      Description
      OverviewA cell-permeable triazine based compound that inhibits Ca2+-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content, without affecting enlargeosomes or other membrane-bound organelles. It does not disturb the organization of the actin or tubulin cytoskeletal network, nor does it interfere with membrane traffic along the constitutive pathway from the ER to the plasma membrane.
      Catalogue Number673000
      Brand Family Calbiochem®
      References
      ReferencesCerny, J., et al. 2004. EMBO Rep. 5, 883.
      Product Information
      CAS number351986-85-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₆H₂₄IN₇O
      Chemical formulaC₂₆H₂₄IN₇O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCa2+-dependent fusion of lysosomes with the plasma membrane
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      673000-10MG 04055977183511

      Documentation

      Vacuolin-1 - CAS 351986-85-1 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Vacuolin-1 - CAS 351986-85-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      673000

      References

      Reference overview
      Cerny, J., et al. 2004. EMBO Rep. 5, 883.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      DescriptionA cell-permeable triazine-based compound that inhibits Ca2+-dependent exocytosis of lysosomes induced by ionomycin or plasma membrane wounding. Does not affect the resealing process and the exocytosis of enlargeosomes. It also does not disturb the organization of the actin or tubulin cytoskeletal network or interfere with membrane traffic along the constitutive pathway from the ER to the plasma membrane.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number351986-85-1
      Chemical formulaC₂₆H₂₄IN₇O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesCerny, J., et al. 2004. EMBO Rep. 5, 883.