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662041 U-73343 - CAS 142878-12-4 - Calbiochem

A cell-permeable analog of U-73122 that acts as a very weak inhibitor of phospholipase C. Suitable as a negative control.

U-73343 - CAS 142878-12-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-[6-((17β-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-2,5-pyrrolidinedione

Primary Target: Negative control of U-73122 in the inhibition of phospholipase C
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662041
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
142878-12-4C₂₉H₄₂N₂O₃

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      Description
      OverviewA cell-permeable analog of U-73122 (Cat. No. 662035) that acts as a very weak inhibitor of phospholipase C. Suitable as a negative control.
      Catalogue Number662041
      Brand Family Calbiochem®
      Synonyms1-[6-((17β-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-2,5-pyrrolidinedione
      References
      ReferencesTatrai, A., et al. 1994. Biochim. Biophys. Acta 1224, 595.
      Bleasdale, J.E., et al. 1990. J. Pharmacol. Exp. Ther. 255, 756.
      Smith, R.J., et al. 1990. J. Pharmacol. Exp. Ther. 253, 688.
      Product Information
      CAS number142878-12-4
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₂₉H₄₂N₂O₃
      Chemical formulaC₂₉H₄₂N₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNegative control of U-73122 in the inhibition of phospholipase C
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFor storage in chloroform, aliquot into single use volumes, evaporate to dryness under a stream of nitrogen and freeze (-20°C). DMSO stocks solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      662041-5MG 04055977261066

      Documentation

      U-73343 - CAS 142878-12-4 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      U-73343 - CAS 142878-12-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      662041

      References

      Reference overview
      Tatrai, A., et al. 1994. Biochim. Biophys. Acta 1224, 595.
      Bleasdale, J.E., et al. 1990. J. Pharmacol. Exp. Ther. 255, 756.
      Smith, R.J., et al. 1990. J. Pharmacol. Exp. Ther. 253, 688.

      Citations

      Title
    • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
    • Di Zhang, et al. (2005) Strontium Promotes Calcium Oscillations in Mouse Meiotic Oocytes and Early Embryos Through InsP3 Receptors, and Requires Activation of Phopsholipase and the Synertistic Action of InsP3. Human Reproduction in press,.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-February-2024 JSW
      Synonyms1-[6-((17β-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-2,5-pyrrolidinedione
      DescriptionA cell-permeable analog of U-73122 (Cat. No. 662035) that acts as a very weak inhibitor of phospholipase C. Suitable as a negative control.
      FormOff-white solid
      CAS number142878-12-4
      Chemical formulaC₂₉H₄₂N₂O₃
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityChloroform (200 mg/ml), DMSO (2 mg/ml), or Ethanol (1 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFor storage in chloroform, aliquot into single use volumes, evaporate to dryness under a stream of nitrogen and freeze (-20°C). DMSO stocks solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      ReferencesTatrai, A., et al. 1994. Biochim. Biophys. Acta 1224, 595.
      Bleasdale, J.E., et al. 1990. J. Pharmacol. Exp. Ther. 255, 756.
      Smith, R.J., et al. 1990. J. Pharmacol. Exp. Ther. 253, 688.
      Citation
    • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
    • Di Zhang, et al. (2005) Strontium Promotes Calcium Oscillations in Mouse Meiotic Oocytes and Early Embryos Through InsP3 Receptors, and Requires Activation of Phopsholipase and the Synertistic Action of InsP3. Human Reproduction in press,.
      		•