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654255 TNF-α Antagonist - Calbiochem

The TNF-α Antagonist controls the biological activity of TNF-α.

TNF-α Antagonist - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: TNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I

Primary Target: TNF-α
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654255
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₅₈H₇₁N₁₁O₁₅S₂

Pricing & Availability

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654255-1MG
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      Description
      OverviewAn exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in the binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. The designation WP9QY arises from the binding to the site observed in the TNF-β/TNF-receptor (I) complex as template, and the introduction of amino acids Glu and Tyr.
      Catalogue Number654255
      Brand Family Calbiochem®
      SynonymsTNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
      References
      ReferencesTakasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.
      Product Information
      ATP CompetitiveN
      DeclarationSold under license of U.S. Patent 6,265,535.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₅₈H₇₁N₁₁O₁₅S₂
      Chemical formulaC₅₈H₇₁N₁₁O₁₅S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTNF-α
      Primary Target IC<sub>50</sub>5 µM as TNF-α antagonist
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceH-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      654255-1MG 04055977184624

      Documentation

      TNF-α Antagonist - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      TNF-α Antagonist - Calbiochem Certificates of Analysis

      TitleLot Number
      654255

      References

      Reference overview
      Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-November-2013 JSW
      SynonymsTNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
      DescriptionAn exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₅₈H₇₁N₁₁O₁₅S₂
      Peptide SequenceH-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml) or 5% Acetic Acid (5 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
      Toxicity Standard Handling
      ReferencesTakasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.