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5677 Spermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem

Polyamine that plays an important role in the regulation of cellular proliferation and differentiation.

Spermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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5677
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
306-67-2C₁₀H₂₆N₄ . 4HCl

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5677-5GM
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      Description
      OverviewPolyamine that plays an important role in the regulation of cellular proliferation and differentiation. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Acts as an inhibitor of phospholipase Cα and an activator of phospholipase Cδ. Inhibits DNA fragmentation and morphological apoptosis. Inhibits neuronal NOS.
      Catalogue Number5677
      Brand Family Calbiochem®
      References
      ReferencesIgarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101.
      Escargueil-Blanc, I., et al. 1994. FASEB J. 8, 1075.
      Hu, J., et al. 1994. Neurosci. Lett. 175, 41.
      Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta 1206, 1208.
      Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int. 32, 1085.
      Svensson, F., et al. 1993. Mol. Cell. Biochem. 124, 141.
      Ask, A., et al. 1992. Cancer Lett. 66, 29.
      Chida, N., et al. 1992. Brain Res. 593, 57.
      Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 11428.
      Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585.
      Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys. 297, 328.
      Shantz, L.M., et al. 1992. Biochem. J. 288, 511.
      Product Information
      CAS number306-67-2
      FormWhite solid
      Hill FormulaC₁₀H₂₆N₄ . 4HCl
      Chemical formulaC₁₀H₂₆N₄ . 4HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetphospholipase C α
      Secondary targetnNOS
      Purity≥99% by titration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSEJ7230000
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C under inert gas.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5677-5GM 04055977190939

      Documentation

      Spermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Spermine, Tetrahydrochloride - CAS 306-67-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      5677

      References

      Reference overview
      Igarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101.
      Escargueil-Blanc, I., et al. 1994. FASEB J. 8, 1075.
      Hu, J., et al. 1994. Neurosci. Lett. 175, 41.
      Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta 1206, 1208.
      Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int. 32, 1085.
      Svensson, F., et al. 1993. Mol. Cell. Biochem. 124, 141.
      Ask, A., et al. 1992. Cancer Lett. 66, 29.
      Chida, N., et al. 1992. Brain Res. 593, 57.
      Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 11428.
      Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585.
      Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys. 297, 328.
      Shantz, L.M., et al. 1992. Biochem. J. 288, 511.

      Brochure

      Title
      Excitotoxic Glutamate Analogs Technical Bulletin
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-October-2007 JSW
      DescriptionPolyamine that plays an important role in the regulation of cellular proliferation and differentiation. Acts as an inhibitor of phopholipase C-α and an activator of phopholipase C-δ. Has both stimulatory and inhibitory effects on NMDA receptors depending on the subunit composition of the receptor. Inhibits neuronal NOS. Inhibits DNA fragmentation and morphological apoptosis.
      FormWhite solid
      CAS number306-67-2
      RTECSEJ7230000
      Chemical formulaC₁₀H₂₆N₄ . 4HCl
      Structure formulaStructure formula
      Purity≥99% by titration
      SolubilityH₂O (20 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C under inert gas.
      Toxicity Irritant
      Merck USA index14, 8743
      ReferencesIgarashi, K. and Williams, K. 1995. J. Pharmacol. Exp. Ther. 272, 1101.
      Escargueil-Blanc, I., et al. 1994. FASEB J. 8, 1075.
      Hu, J., et al. 1994. Neurosci. Lett. 175, 41.
      Tompkins, T.A. and Moscarello, M.A. 1994. Biochim. Biophys. Acta 1206, 1208.
      Trubiani, O., et al. 1994. Biochem. Mol. Biol. Int. 32, 1085.
      Svensson, F., et al. 1993. Mol. Cell. Biochem. 124, 141.
      Ask, A., et al. 1992. Cancer Lett. 66, 29.
      Chida, N., et al. 1992. Brain Res. 593, 57.
      Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 11428.
      Messena, L., et al. 1992. J. Leukoc. Biol. 52, 585.
      Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys. 297, 328.
      Shantz, L.M., et al. 1992. Biochem. J. 288, 511.