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572660 SU11652 - CAS 326914-10-7 - Calbiochem

A cell-permeable pyrrole-indolinone compound that acts as a potent, reversible, and ATP-competitive tyrosine kinase receptor and angiogenic inhibitor.

SU11652 - CAS 326914-10-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, VEGFR Tyrosine Kinase Inhibitor XVII, VEGFR2 Kinase Inhibitor XIV, PDGFR Tyrosine Kinase Inhibitor VIII

Primary Target: PDGFRB
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
326914-10-7C₂₂H₂₇ClN₄O₂

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      Description
      OverviewA cell-permeable pyrrole-indolinone compound that acts as a potent, reversible, and ATP-competitive tyrosine kinase receptor and angiogenic inhibitor that exhibits greater selectivity for PDGFRβ (IC50 = 3 nM), VEGFR2 (IC50 = 27 nM), FGFR1 (IC50 = 170 nM), and Kit family members (IC50 = ~ 10-500 nM) over EGFR (IC50 >20 µM). Reported to display anti-proliferative and pro-apoptotic properties in tumor cells.
      Catalogue Number572660
      Brand Family Calbiochem®
      Synonyms5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, VEGFR Tyrosine Kinase Inhibitor XVII, VEGFR2 Kinase Inhibitor XIV, PDGFR Tyrosine Kinase Inhibitor VIII
      References
      ReferencesHeryanto, B., et al. 2003. Reproduction 125, 334.
      Sun, L., et al. 2003. J. Med. Chem. 46, 1116.
      Liao, A.T., et al. 2002. Blood 100, 585.
      Product Information
      CAS number326914-10-7
      ATP CompetitiveY
      FormOrange powder
      Hill FormulaC₂₂H₂₇ClN₄O₂
      Chemical formulaC₂₂H₂₇ClN₄O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPDGFRB
      Primary Target IC<sub>50</sub>3 nM, 27 nM, 170 nM against PDGFRβ, VEGFR2, and FGFR1, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      572660-500UG 04055977266320

      Documentation

      SU11652 - CAS 326914-10-7 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      SU11652 - CAS 326914-10-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      572660

      References

      Reference overview
      Heryanto, B., et al. 2003. Reproduction 125, 334.
      Sun, L., et al. 2003. J. Med. Chem. 46, 1116.
      Liao, A.T., et al. 2002. Blood 100, 585.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-September-2010 JSW
      Synonyms5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[2-(diethylamino)ethyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, VEGFR Tyrosine Kinase Inhibitor XVII, VEGFR2 Kinase Inhibitor XIV, PDGFR Tyrosine Kinase Inhibitor VIII
      DescriptionA cell-permeable, potent, reversible, and ATP-competitive inhibitor of tyrosine kinase activity of PDGFRβ (IC50 = 3 nM), VEGFR2 (IC50 = 27 nM), FGFR1 (IC50 = 170 nM), and Kit family members (IC50 ~10-500 nM). Does not effect the activity of EGFR (IC50 >20 µM). Reported to display anti-proliferative, antiangiogenic and pro-apoptotic properties in tumor cells.
      FormOrange powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number326914-10-7
      Chemical formulaC₂₂H₂₇ClN₄O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (4 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesHeryanto, B., et al. 2003. Reproduction 125, 334.
      Sun, L., et al. 2003. J. Med. Chem. 46, 1116.
      Liao, A.T., et al. 2002. Blood 100, 585.