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SCC289 SF295 Human Glioblastoma Cell Line

SF295 human glioblastoma cell line is a valuable model for glioblastoma research.

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SCC289
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC289
      DescriptionSF295 Human Glioblastoma Cell Line
      Alternate Names
      • SF-295
      • SF 295
      Background InformationGlioblastoma multiforme is the most common and malignant primary brain tumor in adults, with a high recurrence rate and a five-year survival rate of less than 5% (1). Nearly 50% of glioblastomas originate in the temporal lobes of the brain (1). Glioblastomas are the most aggressive form of cancer and demonstrate a high degree of chemotherapy resistance, highlighting the importance of relevant human patient-derived cell models for advancing research into characteristics and treatment of this disease.

      SF295 is a patient-derived glioblastoma cell line originating from a temporal lobe tumor (2). SF295 cells do not express the glial markers GFAP or glutamine synthetase, but have been shown to positively express neurofibromin-1, identified as one of the most frequently mutated factors in glioblastoma multiforme (3). SF295 cells exhibit hypertriploidy and glial-like morphology in culture and are non-tumorigenic in athymic mice (2). The SF295 cell line is highly published in studies of chemotherapeutic treatments for glioblastoma, representing a valuable cellular model for assessment of drugs and molecular modulators for their effect on glioblastomas.

      Source:
      The SF295 glioblastoma cell line was derived from the temporal lobe tumor of a 67-year-old female patient (2).

      References:
      1. Clin J Oncol Nurs. 2016; 20(5 Suppl): S2-8.
      2. Acta Neuropathol. 1987; 75(1): 92-103.
      3. Mol Cancer Ther. 2010; 9(5): 1234-43.
      References
      Product Information
      Applications
      ApplicationSF295 human glioblastoma cell line is a valuable model for glioblastoma research.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC289 04061842104031