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559393 SB 202190, Hydrochloride - CAS 350228-36-3 - Calbiochem

A water-soluble form of the potent p38 MAP kinase inhibitor SB 202190.

SB 202190, Hydrochloride - CAS 350228-36-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride

Primary Target: p38β
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559393
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
350228-36-3C₂₀H₁₄FN₃O · HCl

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      Description
      OverviewA water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).
      Catalogue Number559393
      Brand Family Calbiochem®
      Synonyms4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride
      References
      Product Information
      CAS number350228-36-3
      ATP CompetitiveY
      FormAmber solid
      Hill FormulaC₂₀H₁₄FN₃O · HCl
      Chemical formulaC₂₀H₁₄FN₃O · HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetp38β
      Primary Target IC<sub>50</sub>350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)
      Primary Target K<sub>i</sub>16 nM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      559393-1MG 04055977192544

      Documentation

      SB 202190, Hydrochloride - CAS 350228-36-3 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      SB 202190, Hydrochloride - CAS 350228-36-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      559393

      Citations

      Title
    • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
    • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)1H-imidazole, HCl, p38 MAP Kinase Inhibitor II, Hydrochloride
      DescriptionA water-soluble form of the potent p38 MAP kinase inhibitor SB 202190 (Cat. No. 559388).
      FormAmber solid
      CAS number350228-36-3
      Chemical formulaC₂₀H₁₄FN₃O · HCl
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO or slightly soluble in H₂O (0.5 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
      Toxicity Standard Handling
      Citation
    • Patrick Michl, et al. (2005) CUTL1 is a target of TGFβ signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532.
    • Yung-Luen Yu, et al. (2005) MAP kinase-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival. Journal of Biological Chemistry 280, 29533-29542.
      		•

      Related Products & Applications

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      Catalogue Number Description  
      559388 SB 202190 - CAS 152121-30-7 - Calbiochem Show Pricing & Availability

      Categories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > MAP Kinase Inhibitors