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557550 Ro106-9920

A cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties.

Ro106-9920 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: IκBαee ubiquitination
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557550
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
62645-28-7C₁₀H₇N₅OS

Pricing & Availability

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557550-1MG
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      Description
      OverviewA cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties. Acts as a highly selective, irreversible inhibitor of IκBαee ubiquitination (IC50 = 2.3 µM). Blocks NF-κB-dependent cytokine expression in human PBMNs (IC50’s = ~ 700 nM for TNF-α, IL-1β, and IL-6 inhibition) and rats. Does not inhibit SCFβTRCP(IκBα ubiquitin ligase)-mediated β-catenin ubiquitination in Jurkat cells. At 10 µM concentrations, also inhibits the activities of 5-lipoxygenase (by 89%) and EGFR kinase (by 63%).
      Catalogue Number557550
      Brand Family Calbiochem®
      References
      ReferencesSwinney, D.C., et al. 2002. J. Biol. Chem. 277, 23573.
      Product Information
      CAS number62645-28-7
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₀H₇N₅OS
      Chemical formulaC₁₀H₇N₅OS
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetIκBαee ubiquitination
      Primary Target IC<sub>50</sub>2.3 µM against IκBαee ubiquitination
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      557550-1MG 04055977193015

      Documentation

      Ro106-9920 MSDS

      Title

      Safety Data Sheet (SDS) 

      Ro106-9920 Certificates of Analysis

      TitleLot Number
      557550

      References

      Reference overview
      Swinney, D.C., et al. 2002. J. Biol. Chem. 277, 23573.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-April-2009 JSW
      DescriptionA cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties. Acts as a highly selective, irreversible inhibitor of IκBαee ubiquitination (IC50 = 2.3 µM). Also reported to prevent degradation of IκBαee in MM6 cells (complete inhibition at ~3-5 µM). Shown to block NF-κB-dependent cytokine expression in human peripheral blood mononuclear cells (PBMN) (IC50 = 600-700 nM for TNF-α, IL-1β, and IL-6 inhibition). Also shown to lower circulating levels of TNFα in LPS-treated rats. Also shown to inhibit 5-lipoxygenase (89% inhibition) and EGFR kinase (63% inhibition) at higher concentrations (10 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number62645-28-7
      Chemical formulaC₁₀H₇N₅OS
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml) or Ethanol (1 mg/ml)
      Storage Protect from moisture
      Protect from light
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
      Toxicity Standard Handling
      ReferencesSwinney, D.C., et al. 2002. J. Biol. Chem. 277, 23573.