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557502 Ro-20-1724 - CAS 29925-17-5 - Calbiochem

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 2 µM).

Ro-20-1724 - CAS 29925-17-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

Primary Target: PDE IV
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
29925-17-5C₁₅H₂₂N₂O₃

Pricing & Availability

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557502-100MG
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      Description
      OverviewA cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50 = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.
      Catalogue Number557502
      Brand Family Calbiochem®
      Synonyms4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
      References
      ReferencesDerian, C.K., et al. 1995. J. Immunol. 154, 308.
      Rubin, L.L., et al. 1991. J. Cell Biol. 115, 1725.
      Lad, P.M., et al. 1985. Biochim. Biophys. Acta 846, 286.
      Bergstrand, H., et al. 1977. Mol. Pharmacol. 13, 38.
      Product Information
      CAS number29925-17-5
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₅H₂₂N₂O₃
      Chemical formulaC₁₅H₂₂N₂O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPDE IV
      Primary Target IC<sub>50</sub>2 µM against PDE IV
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      557502-100MG 04055977268119

      Documentation

      Ro-20-1724 - CAS 29925-17-5 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Ro-20-1724 - CAS 29925-17-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      557502

      References

      Reference overview
      Derian, C.K., et al. 1995. J. Immunol. 154, 308.
      Rubin, L.L., et al. 1991. J. Cell Biol. 115, 1725.
      Lad, P.M., et al. 1985. Biochim. Biophys. Acta 846, 286.
      Bergstrand, H., et al. 1977. Mol. Pharmacol. 13, 38.

      Citations

      Title
    • Ryan W Carlin, et al. (2006) PVD9902, a porcine vas deferens epithelial cell line that exhibits neurotransmitter-stimulated anion secretion and expresses numerous HCO3- transporters. American Journal of Physiology Cell Physiology 290, C1560-C1571.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-September-2008 RFH
      Synonyms4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
      DescriptionSelective inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC50 = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.
      FormWhite solid
      CAS number29925-17-5
      Chemical formulaC₁₅H₂₂N₂O₃
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (20%) or ethanol (4%)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Toxicity Irritant
      ReferencesDerian, C.K., et al. 1995. J. Immunol. 154, 308.
      Rubin, L.L., et al. 1991. J. Cell Biol. 115, 1725.
      Lad, P.M., et al. 1985. Biochim. Biophys. Acta 846, 286.
      Bergstrand, H., et al. 1977. Mol. Pharmacol. 13, 38.
      Citation
    • Ryan W Carlin, et al. (2006) PVD9902, a porcine vas deferens epithelial cell line that exhibits neurotransmitter-stimulated anion secretion and expresses numerous HCO3- transporters. American Journal of Physiology Cell Physiology 290, C1560-C1571.
      		•