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559285 RSK Inhibitor, SL0101

RSK Inhibitor, SL0101, CAS 77307-50-7, is a cell-permeable, selective, reversible, ATP-competitive RSK inhibitor (IC50 = 89 nM with 10 µM ATP). Blocks the proliferation of MCF-7 cell line.

RSK Inhibitor, SL0101 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Kaempferol-3-O-(3ʹʹ,4ʹʹ-di-O-acetyl-α-L-rhamnopyranoside), p90 Ribosomal S6 Kinase Inhibitor, SL0101

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559285
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
77307-50-7C₂₅H₂₄O₁₂

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      Description
      OverviewA cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM. Also available as a 10 mM solution in DMSO (Cat. No. 559292).
      Catalogue Number559285
      Brand Family Calbiochem®
      SynonymsKaempferol-3-O-(3ʹʹ,4ʹʹ-di-O-acetyl-α-L-rhamnopyranoside), p90 Ribosomal S6 Kinase Inhibitor, SL0101
      References
      ReferencesSmith, J.A., et al. 2007. Bioorg. Med. Chem. 15, 5018.
      Smith, J.A., et al. 2006. Bioorg. Med. Chem. 14, 6043.
      Xu, Y.M., et al. 2006. Bioorg. Med. Chem. 14, 3974.
      Maloney, D.J. and Hecht, S.M., 2005. Org. Lett. 7, 1097.
      Smith, J.A., et al. 2005. Cancer Res. 65, 1027.
      Product Information
      CAS number77307-50-7
      FormYellow solid
      Hill FormulaC₂₅H₂₄O₁₂
      Chemical formulaC₂₅H₂₄O₁₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationRSK Inhibitor, SL0101, CAS 77307-50-7, is a cell-permeable, selective, reversible, ATP-competitive RSK inhibitor (IC50 = 89 nM with 10 µM ATP). Blocks the proliferation of MCF-7 cell line.
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Regulatory Review
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      559285-1MG 04055977192360

      Documentation

      RSK Inhibitor, SL0101 MSDS

      Title

      Safety Data Sheet (SDS) 

      RSK Inhibitor, SL0101 Certificates of Analysis

      TitleLot Number
      559285

      References

      Reference overview
      Smith, J.A., et al. 2007. Bioorg. Med. Chem. 15, 5018.
      Smith, J.A., et al. 2006. Bioorg. Med. Chem. 14, 6043.
      Xu, Y.M., et al. 2006. Bioorg. Med. Chem. 14, 3974.
      Maloney, D.J. and Hecht, S.M., 2005. Org. Lett. 7, 1097.
      Smith, J.A., et al. 2005. Cancer Res. 65, 1027.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-October-2014 JSW
      SynonymsKaempferol-3-O-(3ʹʹ,4ʹʹ-di-O-acetyl-α-L-rhamnopyranoside), p90 Ribosomal S6 Kinase Inhibitor, SL0101
      DescriptionA cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number77307-50-7
      Chemical formulaC₂₅H₂₄O₁₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Regulatory Review
      ReferencesSmith, J.A., et al. 2007. Bioorg. Med. Chem. 15, 5018.
      Smith, J.A., et al. 2006. Bioorg. Med. Chem. 14, 6043.
      Xu, Y.M., et al. 2006. Bioorg. Med. Chem. 14, 3974.
      Maloney, D.J. and Hecht, S.M., 2005. Org. Lett. 7, 1097.
      Smith, J.A., et al. 2005. Cancer Res. 65, 1027.