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557403 RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem

RNA Polymerase III Inhibitor, CAS 577784-91-9, is a cell-permeable inhibitor of RNA Polymerase III (IC₅₀ = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively).

RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ML-60218, N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide

Primary Target: activity against RNA Polymerase III
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557403
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Overview

Key Spec Table

CAS #Empirical Formula
577784-91-9C₁₉H₁₅Cl₂N₃O₂S₂

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557403-10MG
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      Description
      OverviewA cell-permeable indazolo-sulfonamide compound that displays broad-spectrum inhibitory activity against RNA Polymerase III (IC50 = 27 and 32 µM for human and S. cerevisiae RNA Pol III, respectively). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. Also available as a 25 mM solution in DMSO (Cat. No. 557404).
      Catalogue Number557403
      Brand Family Calbiochem®
      SynonymsML-60218, N-[1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl)]-2-chlorobenzenesulfonamide
      References
      ReferencesWu, L., et al. 2003. Euk. Cell 2, 256.
      Product Information
      CAS number577784-91-9
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₉H₁₅Cl₂N₃O₂S₂
      Chemical formulaC₁₉H₁₅Cl₂N₃O₂S₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary Targetactivity against RNA Polymerase III
      Primary Target IC<sub>50</sub>27 and 32 µM for Human and S. cerevisiae RNA Pol III
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      557403-10MG 04055977268058