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529573 PP2 - CAS 172889-27-9 - Calbiochem

PP2, CAS 172889-27-9, is a potent, reversible, ATP-competitive, inhibitor of the Src family of protein tyrosine kinases (IC₅₀ = 4, 5, 5, &100 nM for p56lck, p59fynT, Hck, & Src, respectively).

PP2 - CAS 172889-27-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: AG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine

Primary Target: p56lck
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529573
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Overview

Key Spec Table

CAS #Empirical Formula
172889-27-9C₁₅H₁₆ClN₅

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          Description
          OverviewA potent, reversible, ATP-competitive, and selective inhibitor of the Src family of protein tyrosine kinases. Inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), Hck (IC50 = 5 nM), and Src (IC50 = 100 nM). Does not significantly affect the activity of EGFR kinase (IC50 = 480 nM), JAK2 (IC50 > 50 µM), or ZAP-70 (IC50 >100 µM). Inhibits the activation of focal adhesion kinase and its phosphorylation at Tyr577. Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC50 = 600 nM). A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529576) in DMSO also available.
          Catalogue Number529573
          Brand Family Calbiochem®
          SynonymsAG 1879, 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine
          References
          ReferencesKarni, R., et al. 2003. FEBS Lett. 537, 47.
          Salazar, E.P., and Rozengurt, E. 1999. J. Biol. Chem. 274, 28371.
          Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695.



          Selected Citations
          Lee, J., et al. 2009. Cell Stem Cell 5, 76.
          Product Information
          CAS number172889-27-9
          ATP CompetitiveY
          FormOff-white solid
          Hill FormulaC₁₅H₁₆ClN₅
          Chemical formulaC₁₅H₁₆ClN₅
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Biological Information
          Primary Target p56lck
          Primary Target IC<sub>50</sub>4 nM, 5 nM, 5 nM, 100 nM, against p56lck, p59fynT, Hck, and Src, respectively; 600 nM against anti-CD3-stimulated tyrosine phosphorylation of human T cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Global Trade Item Number
          Catalogue Number GTIN
          529573-1MG 07790788051198
          529573-5MG 04055977269802