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529599 PP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem

A cell-permeable 3-MB-PP1 analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux in Syk MASA-expressing DT40 cells.

PP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Syk ASKA Inhibitor II, PDK1 ASKA Inhibitor, 4-Amino-1-tert-butyl-3-(2,3-dimethylbenzyl)pyrazolo[3,4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

529599
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
956026-24-7C₁₈H₂₃N₅

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529599-10MG
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      Description
      OverviewA cell-permeable 3-MB-PP1 (Cat. No. 529582) analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1 µM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells.
      Catalogue Number529599
      Brand Family Calbiochem®
      SynonymsSyk ASKA Inhibitor II, PDK1 ASKA Inhibitor, 4-Amino-1-tert-butyl-3-(2,3-dimethylbenzyl)pyrazolo[3,4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
      References
      ReferencesMiller, A.L., et al. 2009. J. Immunol. 182, 988.
      Tamguney, T., et al. 2008. Exp. Cell Res. 314, 2299.
      Product Information
      CAS number956026-24-7
      FormOff-white powder
      Hill FormulaC₁₈H₂₃N₅
      Chemical formulaC₁₈H₂₃N₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      529599-10MG 04055977269925

      Documentation

      PP1 Analog V, 2,3-DMB-PP1 - CAS 956026-24-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      529599

      References

      Reference overview
      Miller, A.L., et al. 2009. J. Immunol. 182, 988.
      Tamguney, T., et al. 2008. Exp. Cell Res. 314, 2299.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2012 JSW
      SynonymsSyk ASKA Inhibitor II, PDK1 ASKA Inhibitor, 4-Amino-1-tert-butyl-3-(2,3-dimethylbenzyl)pyrazolo[3,4-d]pyrimidine, 1-tert-Butyl-3-(2,3-dimethylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
      DescriptionA cell-permeable 3-MB-PP1 (Cat. No. 529582) analog that is more effective than 3-MB-PP1 in inhibiting SykM442A S505A ASKA- (analog-sensitive kinase alleles) mediated cellular calcium flux (98% vs. 20% inhibition, respectively, by 1 µM 2,3-DMB-PP1 or 3-MB-PP1) in Syk MASA-expressing DT40 cells. Also shown to selectively inhibit L159G ASKA, but not wt, PDK1-dependent GSK3&alpha Ser21 and S6 Ser235/236 phosphorylation upon IGF1 stimulation in mES cells.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number956026-24-7
      Chemical formulaC₁₈H₂₃N₅
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesMiller, A.L., et al. 2009. J. Immunol. 182, 988.
      Tamguney, T., et al. 2008. Exp. Cell Res. 314, 2299.