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529505 PON1 Activator, ZNPA - CAS 42172-66-7 - Calbiochem

The PON1 Activator, ZNPA modulates the biological activity of PON1. This small molecule/inhibitor is primarily used for Biochemicals applications.

PON1 Activator, ZNPA - CAS 42172-66-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (Z)-2,3-bis (4-nitrophenyl)-acrylonitrile

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
42172-66-7C₁₅H₉N₃O₄

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      Description
      OverviewA cell-permeable stilbene derivative that serves as an aryl hydrocarbon receptor (AhR) ligand and acts as a highly specific and potent inducer of paraoxonase 1 (PON1). Shown to be a better activator of PON1 mRNA (EC50 = 1 µM) and inducer of PON1 enzymatic activity (> 3 fold at 5 µM) when compared to resveratrol (Cat. No. 554325). However, it is devoid of any activity against estrogen receptors and is not shown to inhibit activity of tyrosine kinases. Also shown to antagonize the effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on cytochrome P450 1A1 (CYP1A1).
      Catalogue Number529505
      Brand Family Calbiochem®
      Synonyms(Z)-2,3-bis (4-nitrophenyl)-acrylonitrile
      References
      ReferencesGuyot, E., et al. 2011. Biochem. Pharm. 83, 627.
      Product Information
      CAS number42172-66-7
      FormPale yellow solid
      Hill FormulaC₁₅H₉N₃O₄
      Chemical formulaC₁₅H₉N₃O₄
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      529505-10MG 04055977269673

      Documentation

      PON1 Activator, ZNPA - CAS 42172-66-7 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      PON1 Activator, ZNPA - CAS 42172-66-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      529505

      References

      Reference overview
      Guyot, E., et al. 2011. Biochem. Pharm. 83, 627.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2012 JSW
      Synonyms(Z)-2,3-bis (4-nitrophenyl)-acrylonitrile
      DescriptionA cell-permeable stilbene derivative that serves as an aryl hydrocarbon receptor (AhR) ligand and acts as a highly specific and potent inducer of paraoxonase 1 (PON1). Shown to be a better activator of PON1 mRNA (EC50 = 1 µM) and inducer of PON1 enzymatic activity (> 3 fold at 5 µM) when compared to resveratrol (Cat. No. 554325). However, it is devoid of any activity against estrogen receptors and is not shown to inhibit activity of tyrosine kinases. Also shown to antagonize the effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on cytochrome P450 1A1 (CYP1A1).
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number42172-66-7
      Chemical formulaC₁₅H₉N₃O₄
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (25 mg/ml; pale yellow solution)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGuyot, E., et al. 2011. Biochem. Pharm. 83, 627.