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14-467M PDGFRα Protein, active, 250 µg

Active, recombinant human PDGFRα, residues 550-end, containing an N-terminal His6-tag, for use in Kinase Assays.

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14-467M
250 µg  Also available in 50 μg size (cat#14-467) and in bulk (cat# 14-467-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-467M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPDGFRα Protein, active, 250 µg
      OverviewRecombinant human PDGFRα, residues 550-end, containing an N-terminal His6-tag
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, recombinant human PDGFRα, residues 550-end, containing an N-terminal His6-tag, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed by baculovirus in Sf21 insect cells
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
      Gene Symbol
      • PDGFRA
      • CD140a
      • PDGF-R-alpha
      • MGC74795
      • PDGFR2
      • Rhe-PDGFRA
      • CD140A
      Protein TargetPDGFRα
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16234 # Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
      SIZE: 1089 amino acids; 122670 Da
      SUBUNIT: Homodimer, and heterodimer with PDGFRB. Interacts with SHB (By similarity).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DISEASE: SwissProt: P16234 # A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage.
      SIMILARITY: SwissProt: P16234 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.
      Molecular Weight63.5kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of Poly (Glu4-Tyr) (4:1) substrate peptide
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 50 μg size (cat#14-467) and in bulk (cat# 14-467-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-467M 04053252469930

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-467 PDGFRα Protein, active, 50 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases