513024 Sigma-AldrichPD 151746 - CAS 179461-52-0 - Calbiochem
A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain.
More>> A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Less<<PD 151746 - CAS 179461-52-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 179461-52-0 | C₁₁H₈FNO₂ |
| Description | |
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| Overview | This product has been discontinued. A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Displays over 20-fold greater selectivity for calpain-1 (Cat. Nos. 208712 and 208713) over calpain-2 (Cat. Nos. 208715 and 208718) (Ki values: 260 nM and 5.33 µM, respectively). Has been shown to prevent cycloheximide-induced apoptosis. |
| Catalogue Number | 513024 |
| Brand Family | Calbiochem® |
| Synonyms | 3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic Acid |
| References | |
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| References | Squier, M.K., et al. 1999. J. Cell Physiol. 178, 311. Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687. |
| Product Information | |
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| CAS number | 179461-52-0 |
| ATP Competitive | N |
| Form | Orange solid |
| Hill Formula | C₁₁H₈FNO₂ |
| Chemical formula | C₁₁H₈FNO₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | calpain-1 |
| Primary Target K<sub>i</sub> | 260 nM against calpain-1 |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 513024 | 0 |
Documentation
PD 151746 - CAS 179461-52-0 - Calbiochem MSDS
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PD 151746 - CAS 179461-52-0 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 513024 |
References
| Reference overview |
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| Squier, M.K., et al. 1999. J. Cell Physiol. 178, 311. Wang, K.K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 6687. |
Citations
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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