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495620 Olomoucine - CAS 101622-51-9 - Calbiochem

A purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B and related kinases.

Olomoucine - CAS 101622-51-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Olomoucine

Primary Target: p34cdk1/cyclin B
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
101622-51-9C₁₅H₁₈N₆O

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      495620-5MG
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          Description
          OverviewA purine derivative that acts as a potent, reversible and selective inhibitor of p34cdk1/cyclin B (IC50 = 7 µM) and related kinases including p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), and p44 MAP kinase (IC50 = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D (IC50 > 1 mM), and p40cdk6/cyclin D3 (IC50 > 250 µM). Does not significantly affect the activity of other protein kinases at 1 mM. Known to inhibit DNA synthesis in interleukin-2-stimulated T lymphocytes and trigger G1 arrest similar to that observed in interleukin-2-deprived cells. Also used to synchronize cells in G1. A 50 mM (5 mg/336 µl) solution of Olomoucine (Cat. No. 495624) in DMSOis also available.
          Catalogue Number495620
          Brand Family Calbiochem®
          SynonymsOlomoucine
          References
          ReferencesAbraham, R.T., et al. 1995. Biol. Cell 83, 105.
          Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715.
          Glab, N., et al. 1994. FEBS Lett. 353, 207.
          Veselý, J., et al. 1994. Eur. J. Biochem. 224, 771.
          Product Information
          CAS number101622-51-9
          ATP CompetitiveY
          FormCrystalline solid
          Hill FormulaC₁₅H₁₈N₆O
          Chemical formulaC₁₅H₁₈N₆O
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetp34cdk1/cyclin B
          Primary Target IC<sub>50</sub>7 µM, 7 µM, 7 µM, 3 µM, 25 µM against p34cdk1/cyclin B, p33cdk2/cyclin A, p33cdk2/cyclin E, p33cdk5/p35, and p44 MAP kinase, respectively
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          495620-1MG 04055977199789
          495620-5MG 04055977199796

          Documentation

          Olomoucine - CAS 101622-51-9 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          Olomoucine - CAS 101622-51-9 - Calbiochem Certificates of Analysis

          TitleLot Number
          495620

          References

          Reference overview
          Abraham, R.T., et al. 1995. Biol. Cell 83, 105.
          Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715.
          Glab, N., et al. 1994. FEBS Lett. 353, 207.
          Veselý, J., et al. 1994. Eur. J. Biochem. 224, 771.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-April-2018 JSW
          SynonymsOlomoucine
          DescriptionA purine derivative that acts as a potent, reversible, and selective inhibitor of p34cdc2/cyclin B (IC50 = 7 µM) and related kinases, including p33cdk2/cyclin A (IC50 = 7 µM), p33cdk2/cyclin E (IC50 = 7 µM), p33cdk5/p35 (IC50 = 3 µM), and p44MAPK (IC50 = 25 µM). Acts by competing for the ATP binding domain of the kinase. Exhibits reduced sensitivity towards related kinases, p34cdk4/cyclin D1 (IC50 > 1000 µM) and p40cdk6/cyclin D3 (IC50 > 250 µM). Does not significantly affect the activity of other protein kinases even at 1 mM concentrations. Known to inhibit DNA synthesis in interleukin-2 stimulated T lymphocytes and triggers G1 arrest similar to that observed in interleukin-2 deprived cells. Also used to synchronize cells in G1.
          FormCrystalline solid
          CAS number101622-51-9
          Chemical formulaC₁₅H₁₈N₆O
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesAbraham, R.T., et al. 1995. Biol. Cell 83, 105.
          Mistelli, T., and Warren, G. 1995. J. Cell Sci. 108, 2715.
          Glab, N., et al. 1994. FEBS Lett. 353, 207.
          Veselý, J., et al. 1994. Eur. J. Biochem. 224, 771.