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SCC259 OVCAR-5 Human Cancer Cell Line

OVCAR-5 cancer cell line is a good model for metastatic gastrointestinal carcinoma.

SCC259
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC259
      DescriptionOVCAR-5 Human Cancer Cell Line
      Alternate Names
      • OVCAR5
      Background InformationOvarian carcinoma is a prevalent worldwide disease, with over 200,000 new cases diagnosed per year (1). Metastatic gastrointestinal cancer frequently presents as advanced ovarian carcinoma (2). The availability of cellular models that recapitulate the spectrum of forms of ovarian cancer are essential to understanding drug resistance, cellular physiology, and advancing new options for treatment.

      The OVCAR-5 cell line was established from ascites fluid from a non-treated patient with an advanced-stage ovarian tumor (3). The OVCAR-5 cell line has recently been classified as originating from the gastrointestinal tract, not of ovarian origin (4). OVCAR-5 cells harbor a homozygous Gly12Val mutation in the KRAS oncogene and are characterized by migration/invasion ability as well as exhibiting tumorigenicity in nude mice (5). OVCAR-5 cells overexpress claudin-4, a marker that plays a role in cancer malignancy (6). OVCAR-5 cells exhibit aggressive growth and invasion and represent a valuable model for metastatic gastrointestinal carcinoma.

      Source:
      OVCAR-5 was established from ascites fluid from a 67-year-old untreated cancer patient (3).

      References:
      1. Nat Rev Disease Primers 2016; 2: 16061.
      2. J Obstet Gynaecol Can 2003; 25(10): 819-824.
      3. Cancer Res 1997; 57: 850-856.
      4. Nuc Acids Res 2016;44(17): e137.
      5. Gynecol Oncol 2015;138(2): 372-377.
      6. Int J Mol Sci 2011; 12: 1334-1358.
      References
      Product Information
      HS Code3002 59 00
      Applications
      ApplicationOVCAR-5 cancer cell line is a good model for metastatic gastrointestinal carcinoma.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC259 04061842403493