492041 Sigma-AldrichNrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem
The Nrf2 Activator II, AI-1, also referenced under CAS 75483-04-4, modulates the biological activity of Nrf2. This small molecule/inhibitor is primarily used for Biochemicals applications.
More>> The Nrf2 Activator II, AI-1, also referenced under CAS 75483-04-4, modulates the biological activity of Nrf2. This small molecule/inhibitor is primarily used for Biochemicals applications. Less<<Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Ethyl-4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 75483-04-4 | C13H₁₂ClNO₃ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 492041-25MG |
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Botol kaca | 25 mg |
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| Description | |
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| Overview | A cell-permeable chloro-quinolinone compound that selectively and covalently modifies Kelch-like ECH-associated protein 1 (Keap1)-Cys151 and represses Keap1 function and reduces Nrf2 (Nuclear factor erythroid 2-related factor 2)-Keap1 interaction. Shown to stabilize Nrf2 by inhibiting the Keap1-driven ubiquitination of Nrf2 and thereby activating the Nrf2-ARE (antioxidant response element) pathway (EC50 = 2.7 µM in neuroblastoma IMR-32 cells). Offers protection against H2O2 induced oxidative stress, but unlike tert-butylhydroquinone (Cat. No. 286888). AI-1 does not act as a free radical scavenger. Its anti-oxidant effects are mediated via Nrf2 induced antioxidant response. Does not affect mutant ARE where GC are substituted with AT within the core ARE sequence. |
| Catalogue Number | 492041 |
| Brand Family | Calbiochem® |
| Synonyms | Ethyl-4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate |
| References | |
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| References | Hur, W., et al. 2010. Chem. Biol. 17, 537. |
| Product Information | |
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| CAS number | 75483-04-4 |
| Form | Off-white solid |
| Hill Formula | C13H₁₂ClNO₃ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Keap1 |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 492041-25MG | 04055977272772 |
Documentation
Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem MSDS
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Nrf2 Activator II, AI-1 - CAS 75483-04-4 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 492041 |
References
| Reference overview |
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| Hur, W., et al. 2010. Chem. Biol. 17, 537. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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