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492029 NRG1-β1/HRG1-β1 EGF Domain, Human, Recombinant

NRG1-β1/HRG1-β1 EGF Domain, Human, Recombinant MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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492029
  
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      Overview

      Replacement Information

      Key Spec Table

      Purity
      ≥97% by SDS-PAGE
      Description
      Overview

      This product has been discontinued.



      Recombinant, human neuregulin 1-β1/heregulin 1-β1 epidermal growth factor-like domain (NRG1-β1/HRG1-β1 EGF Domain), consisting of amino acids 176-246 and expressed in E. coli. All NRG1 isoforms contain an EGF-like domain that is required for binding directly to the ErbB3 or ErbB4 receptor tyrosine kinases.
      Catalogue Number492029
      Brand Family Calbiochem®
      References
      ReferencesBuonanno, A., and Fischbach, G.D. 2001. Curr. Opin. Neurobiol. 11, 287.
      Adlkofer, K. and Lai, C. 2000. Glia 29, 104.
      Garratt, A.N. et al. 2000. BioEssays 22, 987.
      Karey, K.P., et al. 1988. Cancer Res. 48, 4083.
      Product Information
      FormLyophilized
      FormulationLyophilized from 0.2 µm filtered acetonitrile, TFA, BSA.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityED₅₀ = 0.06-0.3 ng/ml as measured in a serum-free proliferation assay using MCF-7 human breast adenocarcinoma cells.
      Purity≥97% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤1.0 EU/µg protein
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      492029 0

      Documentation

      NRG1-β1/HRG1-β1 EGF Domain, Human, Recombinant MSDS

      Title

      Safety Data Sheet (SDS) 

      NRG1-β1/HRG1-β1 EGF Domain, Human, Recombinant Certificates of Analysis

      TitleLot Number
      492029

      References

      Reference overview
      Buonanno, A., and Fischbach, G.D. 2001. Curr. Opin. Neurobiol. 11, 287.
      Adlkofer, K. and Lai, C. 2000. Glia 29, 104.
      Garratt, A.N. et al. 2000. BioEssays 22, 987.
      Karey, K.P., et al. 1988. Cancer Res. 48, 4083.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-June-2011 RFH
      DescriptionRecombinant, human neuregulin 1-β1/heregulin 1-β1 epidermal growth factor-like domain (NRG1-β1/HRG1-β1 EGF Domain), consisting of amino acids 176-246 and expressed in E. coli. All NRG1 isoforms contain an EGF-like domain that is required for binding directly to the ErbB3 or ErbB4 receptor tyrosine kinases.
      FormLyophilized
      FormulationLyophilized from 0.2 µm filtered acetonitrile, TFA, BSA.
      Purity≥97% by SDS-PAGE
      ContaminantsEndotoxin: ≤1.0 EU/µg protein
      Biological activityED₅₀ = 0.06-0.3 ng/ml as measured in a serum-free proliferation assay using MCF-7 human breast adenocarcinoma cells.
      SolubilityReconstitute to 100 µg/ml with sterile PBS containing ≥1% human or bovine serum albumin.
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution refrigerate (4°C) for short-term storage or aliquot and freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBuonanno, A., and Fischbach, G.D. 2001. Curr. Opin. Neurobiol. 11, 287.
      Adlkofer, K. and Lai, C. 2000. Glia 29, 104.
      Garratt, A.N. et al. 2000. BioEssays 22, 987.
      Karey, K.P., et al. 1988. Cancer Res. 48, 4083.