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475841 Miltefosine - CAS 58066-85-6 - Calbiochem

An ether lipid analog that acts as an inhibitor of CTP:phosphocholine cytidyltransferase and displays remarkable antiproliferative effect both in vitro and in vivo.

Miltefosine - CAS 58066-85-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: HePC, 1-Hexadecylphosphorylcholine

Primary Target: CTP:phosphocholine cytidyltransferase
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      58066-85-6C₂₁H₄₆NO₄P
      Description
      OverviewAn ether lipid analog that acts as an inhibitor of CTP:phosphocholine cytidyltransferase and displays remarkable antiproliferative effect both in vitro and in vivo. Also induces apoptosis mediated by cell-permeable ceramides.
      Catalogue Number475841
      Brand Family Calbiochem®
      SynonymsHePC, 1-Hexadecylphosphorylcholine
      References
      ReferencesWieder, T., et al. 1998. J. Biol. Chem. 273, 11025.
      Wieder, T., et al. 1993. Biochem. J. 291, 561.
      Geilen, C.C., et al. 1992. J. Biol. Chem. 267, 6719.
      Geilen, C.C., et al. 1991. Eur. J. Cancer 27, 1650.
      Product Information
      CAS number58066-85-6
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaC₂₁H₄₆NO₄P
      Chemical formulaC₂₁H₄₆NO₄P
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCTP:phosphocholine cytidyltransferase
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSKH2890000
      Safety Information
      R PhraseR: 20/21/22-36/37/38

      Harmful by inhalation, in contact with skin and if swallowed.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in ethanol or DMSO, aliquot and freeze (-20°C). Stock solutions in ethanol or DMSO are stable for up to 3 months at -20°C. Stock solutions in PBS are stable for up to 24 h at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      475841 0

      Documentation

      Miltefosine - CAS 58066-85-6 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Miltefosine - CAS 58066-85-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      475841

      References

      Reference overview
      Wieder, T., et al. 1998. J. Biol. Chem. 273, 11025.
      Wieder, T., et al. 1993. Biochem. J. 291, 561.
      Geilen, C.C., et al. 1992. J. Biol. Chem. 267, 6719.
      Geilen, C.C., et al. 1991. Eur. J. Cancer 27, 1650.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-August-2008 RFH
      SynonymsHePC, 1-Hexadecylphosphorylcholine
      DescriptionAn ether lipid analog that acts as an inhibitor of CTP:phosphocholine cytidyltransferase. Reported to exhibit anti-proliferative and anti-metastatic effects in vitro and in vivo. Also reported to induce apoptosis mediated by cell-permeable ceramides. Shown to have anti-protozoal activity against Leishmania species.
      FormCrystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number58066-85-6
      RTECSKH2890000
      Chemical formulaC₂₁H₄₆NO₄P
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (800 μg/ml), Ethanol (1 mg/ml), or PBS, pH 7.2 (2.5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in ethanol or DMSO, aliquot and freeze (-20°C). Stock solutions in ethanol or DMSO are stable for up to 3 months at -20°C. Stock solutions in PBS are stable for up to 24 h at -20°C.
      Toxicity Harmful
      ReferencesWieder, T., et al. 1998. J. Biol. Chem. 273, 11025.
      Wieder, T., et al. 1993. Biochem. J. 291, 561.
      Geilen, C.C., et al. 1992. J. Biol. Chem. 267, 6719.
      Geilen, C.C., et al. 1991. Eur. J. Cancer 27, 1650.