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444258 MMP-14 Substrate I, Fluorogenic - Calbiochem

A specific fluorescence resonance energy transfer (FRET) peptide substrate for the detection of MMP activity.

MMP-14 Substrate I, Fluorogenic - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MT1-MMP Substrate I, Fluorogenic, MCA-PLA-C(OMeBz)-WAR(Dpa)-NH₂

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444258
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Overview

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      Description
      OverviewA specific fluorescence resonance energy transfer (FRET) peptide substrate for the detection of MMP activity. (kcat/Km = 7.3 x 105 M-1s-1 for MMP-14 (MT1-MMP) and 3.6 x 104 M-1s-1 for MMP-11 at 25°C, pH 7.5).
      Catalogue Number444258
      Brand Family Calbiochem®
      SynonymsMT1-MMP Substrate I, Fluorogenic, MCA-PLA-C(OMeBz)-WAR(Dpa)-NH₂
      References
      ReferencesMucha, A., et al. 1998. J. Biol. Chem. 273, 2763.
      Product Information
      ATP CompetitiveN
      FormYellow lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₆₆H₈₂N₁₆O₁₇S
      Chemical formulaC₆₆H₈₂N₁₆O₁₇S
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-14
      Primary Target IC<sub>50</sub>kcat/Km = 7.3 x 105 M-1s-1 for MMP-14; .6 x 104 M-1s-1 for MMP-11
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceMCA-Pro-Leu-Ala-Cys(p-OMeBz)-Trp-Ala-Arg(Dpa)-NH₂ Dpa = N³-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl, Bz = Benzyl
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      444258-1MG 04055977186550

      Documentation

      MMP-14 Substrate I, Fluorogenic - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      MMP-14 Substrate I, Fluorogenic - Calbiochem Certificates of Analysis

      TitleLot Number
      444258

      References

      Reference overview
      Mucha, A., et al. 1998. J. Biol. Chem. 273, 2763.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-March-2009 JSW
      SynonymsMT1-MMP Substrate I, Fluorogenic, MCA-PLA-C(OMeBz)-WAR(Dpa)-NH₂
      DescriptionA fluorescence resonance energy transfer (FRET) peptide substrate for the detection of MMP activity (kcat/km = 730,000 M-1s-1 for MMP-14 (MT1-MMP) and 36,000 M-1s-1 for MMP-11 (ST3); pH = 7.5 at 25°C). Excitation max.: ~328 nm; emission max.: ~400 nm.
      FormYellow lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₆₆H₈₂N₁₆O₁₇S
      Peptide SequenceMCA-Pro-Leu-Ala-Cys(p-OMeBz)-Trp-Ala-Arg(Dpa)-NH₂ Dpa = N³-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl, Bz = Benzyl
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesMucha, A., et al. 1998. J. Biol. Chem. 273, 2763.