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475864 MK-2 Inhibitor III - CAS 1186648-22-5 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
1186648-22-5C₂₁H₁₆N₄O • H₂O

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475864-5MG
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      Description
      OverviewA cell-permeable pyrrolopyridinyl compound that acts as an ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC50 = 8.5, 81, and 210 nM against MK-2, MK-5, and MK-3, respectively), while exhibiting much less or no activity against 8 other commonly studied kinases. Shown to suppress LPS-induced TNF-α production in U937 cells (IC50 = 4.4 µM).
      Catalogue Number475864
      Brand Family Calbiochem®
      Synonyms2-(2-Quinolin-3-ylpyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo-[3,2-c]pyridin-4-one
      References
      ReferencesAnderson, D.R., et al. 2007. J. Med. Chem. 50, 2647.
      Product Information
      CAS number1186648-22-5
      FormPale yellow solid
      Hill FormulaC₂₁H₁₆N₄O • H₂O
      Chemical formulaC₂₁H₁₆N₄O • H₂O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationMK-2 Inhibitor III, CAS 1186648-22-5, is a cell-permeable, ATP-competitive inhibitor of MK-2/MAPKAP-K2 (IC50 = 8.5, 81 & 210 nM against MK-2, MK-5 & MK-3, respectively).
      Biological Information
      Purity≥97% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      475864-5MG 04055977203400