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119114 Luciferase Inhibitor II - CAS 10205-56-8 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
10205-56-8C₁₅H₁₄N₂S

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119114-5MG
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      Description
      OverviewA 2-arylbenzothiazole compound that acts as an inhibitor against the ATP-dependent Photinus pyralis (lucPpy) and Photuris pennsylvanica (lucPpe) luciferase activity (IC50 = 0.2 and 0.32 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme). Unlike Luciferase Inhibitor I (Cat. No. 119113), Luciferase Inhibitor II is competitive with respect to luciferin and exhibits reduced potency against lucPpe-based commercial luciferase-luciferin formulations with high luciferin concentration (IC50 = 10 µM against Promega's Kinase-Glo®; ineffective against Kinase-Glo® Plus and Kinase-Glo® Max; at a 3-fold formulation dilution and 6.77 µM ATP).
      Catalogue Number119114
      Brand Family Calbiochem®
      Synonyms4-(1,3-Benzothiazol-2-yl)-N,N-dimethylaniline
      References
      ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
      Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
      Product Information
      CAS number10205-56-8
      DeclarationMarketed by Promega Corp. under the registered trademarks.
      FormPale green solid
      Hill FormulaC₁₅H₁₄N₂S
      Chemical formulaC₁₅H₁₄N₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 22-26-36

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      119114-5MG 04055977223248