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540218 LYP Inhibitor II, LTV-1 - Calbiochem

The LYP Inhibitor II, LTV-1 controls the biological activity of LYP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

LYP Inhibitor II, LTV-1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Lymphoid Tyrosine Phosphatase Inhibitor II, LTV-1, (E)-3-((4-((4,6-Dioxo-2-thioxo-1-o-tolyltetrahydropyrimidin-5(6H)-ylidene)methyl)phenoxy)methyl)benzoic acid

Primary Target: LYP
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540218
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₆H₂₀N₂O₅S

Pricing & Availability

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540218-10MG
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      Description
      OverviewA cell-permeable thiobarbituryl-benzoate compound that acts as a highly potent and reversible inhibitor of lymphoid tyrosine phosphatase (LYP) (IC50 = 508 nM) and thereby enhances TCR signaling in intact cells. Exhibits competitive to mixed mode of inhibition (Ki = 384 nM). Also shown to inhibit the mutant, disease associated LYP-Trp620 activity. Binds to the phosphate-binding loop and mimicks the phosphotyrosine moiety of substrates. Displays acceptable selectivity over a wide range of protein phosphatases (TCPTP, PTP1B, PEP (mouse LYP), SHP1, CD45 and PTP-PEST: IC50 = 1.52, 1.59, 7.56, 23.2, 30.1, and 100 µM, respectively). Does not exhibit any toxicity at pharmacological doses when tested in primary human cell lines.
      Catalogue Number540218
      Brand Family Calbiochem®
      SynonymsLymphoid Tyrosine Phosphatase Inhibitor II, LTV-1, (E)-3-((4-((4,6-Dioxo-2-thioxo-1-o-tolyltetrahydropyrimidin-5(6H)-ylidene)methyl)phenoxy)methyl)benzoic acid
      References
      ReferencesVang, T., et al. 2012. Nat. Chem. Biol. 8, 437.
      Product Information
      FormOrange powder
      Hill FormulaC₂₆H₂₀N₂O₅S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetLYP
      Primary Target IC<sub>50</sub>508 nM for LYP
      Secondary targetOthet PTPases
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C>
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      540218-10MG 04055977268720

      Documentation

      LYP Inhibitor II, LTV-1 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      LYP Inhibitor II, LTV-1 - Calbiochem Certificates of Analysis

      TitleLot Number
      540218

      References

      Reference overview
      Vang, T., et al. 2012. Nat. Chem. Biol. 8, 437.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-October-2012 JSW
      SynonymsLymphoid Tyrosine Phosphatase Inhibitor II, LTV-1, (E)-3-((4-((4,6-Dioxo-2-thioxo-1-o-tolyltetrahydropyrimidin-5(6H)-ylidene)methyl)phenoxy)methyl)benzoic acid
      DescriptionA cell-permeable thiobarbituryl-benzoate compound that acts as a highly potent and reversible inhibitor of lymphoid tyrosine phosphatase (LYP) (IC50 = 508 nM) and thereby enhances TCR signaling in intact cells. Exhibits competitive to mixed mode of inhibition (Ki = 384 nM). Also shown to inhibit the mutant, disease associated LYP-Trp620 activity. Binds to the phosphate-binding loop and mimicks the phosphotyrosine moiety of substrates. Displays acceptable selectivity over a wide range of protein phosphatases (TCPTP, PTP1B, PEP (mouse LYP), SHP1, CD45 and PTP-PEST: IC50 = 1.52, 1.59, 7.56, 23.2, 30.1, and 100 µM, respectively). Does not exhibit any toxicity at pharmacological doses when tested in primary human cell lines.
      FormOrange powder
      Intert gas (Yes/No) Packaged under inert gas
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C>
      Toxicity Standard Handling
      ReferencesVang, T., et al. 2012. Nat. Chem. Biol. 8, 437.