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530537 JmjC Histone Demethylase Inhibitor, n-Octyl-IOX1 - CAS 1586038-75-6 - Calbiochem

A cell-permeable, superior inhibitor of Jumonji C domain histone lysine demethylase. About 30 fold more potent than IOX1 (EC₅₀ = 3.8 µM for KDM4A in HeLa cells vs. 100 µM for IOX1).

JmjC Histone Demethylase Inhibitor, n-Octyl-IOX1 - CAS 1586038-75-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: KDM4 Inhibitor

Primary Target: KDM4
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530537
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Overview

Key Spec Table

CAS #Empirical Formula
1586038-75-6C₁₈H₂₃NO₃

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      Description
      OverviewA cell-permeable, non-toxic, n-octyl ester form of 5-carboxy-8-hydroxyquinoline (IOX1, Cat. No. 420201) that acts as a superior inhibitor of Jumonji C domain histone lysine demethylase. Shown to be about 30 fold more potent than IOX1 (EC50 = 3.8 µM for KDM4A in HeLa cells vs. 100 µM for IOX1). Inhibits the H3K9 me3 demethylation activity of KDM4C (IC50 = 3.9 µM in ALPHA Screen assay). Exhibits greater stability to hydrolysis in the ALPHA Screen buffer.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530537
      Brand Family Calbiochem®
      SynonymsKDM4 Inhibitor
      References
      ReferencesSchiller, R., et al. 2014. ChemMedChem. 9,566.
      Product Information
      CAS number1586038-75-6
      FormGrey-green solid
      Hill FormulaC₁₈H₂₃NO₃
      Chemical formulaC₁₈H₂₃NO₃
      ReversibleY
      Quality LevelMQ100
      Biological Information
      Primary TargetKDM4
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.30537.0001 04055977260885